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学科主题: 临床医学
题名:
Is Chronic Kidney Disease Associated with a High Ankle Brachial Index in Adults at High Cardiovascular Risk ?
作者: Liu, Hao1; Shi, Hong2; Yu, Jinming1,3; Chen, Fang4; Jiang, Qingwu1,3; Hu, Dayi5
关键词: Chronic kidney disease ; Ankle brachial index ; Cardiovascular risk ; Diabetes
刊名: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
发表日期: 2011
卷: 18, 期:3, 页:224-230
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PERIPHERAL ARTERIAL-DISEASE ; STAGE RENAL-DISEASE ; MEDIA CALCIFICATION ; ALL-CAUSE ; ATHEROSCLEROSIS RISK ; DISTINCT ENTITIES ; CHINESE PATIENTS ; ELDERLY PERSONS ; MORTALITY RISK ; OUTCOMES
英文摘要:

Aim: Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease (CVD) events. A high ankle brachial index (ABI), a marker of lower arterial stiffness, is associated with CVD events. It remains unknown whether high ABI is associated with CKD. The objectives of this study were to determine the association of CKD with high ABI in adults at high CVD risk.

Methods: The study enrolled hospital-based patients at high CVD risk and measured kidney function and ABI. The glomerular filtration rate (GFR) was estimated using the Modification of Dietin Renal Desease (MDRD) equation and ABI was categorized as low (<0.90), low-normal (0.90 to 1.09), normal (1.10 to 1.40), and high (>= 1.40 or incompressible). Logistic regression was used to evaluate the associations of CKD with ABI categories.

Results: Among 6412 participants, 25% had CKD, 25% had an ABI measurement <0.90, and 1% had an ABI > 1.40. In models adjusted for age, sex, hypertension, diabetes, body mass index, low-density and high-density lipoprotein cholesterol, and smoking, only low ABI was associated with an increased risk of CKD; however, both low ABI (OR: 2.1, 1.6-2.8) and high ABI (OR: 2.4, 1.0-6.4) were associated with an increased risk of CKD in diabetic individuals. Additionally, only low ABI was associated with advanced eGFR levels.

Conclusions: High ABI values are associated with an increased risk of CKD in diabetic individuals at high cardiovascular risk. Future studies are required to speculate whether high ABI might lead to diminished kidney function through nonatherosclerotic pathways and to understand the mechanisms linking them to CVD events and diabetes.

语种: 英语
WOS记录号: WOS:000289530600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59908
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Fudan Univ, Sch Publ Hlth, Clin Res Inst, Shanghai 200032, Peoples R China
2.Fourth Mil Med Univ, Tangdu Hosp, Xian 710038, Peoples R China
3.Fudan Univ, Minist Educ, Key Lab Publ Hlth Safety, Shanghai 200032, Peoples R China
4.Tongji Univ, Sch Med, Dept Prevent Med, Shanghai 200092, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Hao,Shi, Hong,Yu, Jinming,et al. Is Chronic Kidney Disease Associated with a High Ankle Brachial Index in Adults at High Cardiovascular Risk ?[J]. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS,2011,18(3):224-230.
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