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RALY RNA Binding Protein-like Reduced Expression is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma
Cui, Zhi-Wen1,2; Xia, Ye1,2; Ye, Yi-Wang1; Jiang, Zhi-Mao1; Wang, Ya-Dong1; Wu, Jian-Ting1; Sun, Liang3,4,5; Zhao, Jun1; Fa, Ping-Ping1; Sun, Xiao-Juan4,5; Gui, Yao-Ting1; Cai, Zhi-Ming1,3,4
关键词Clear cell renal cell carcinomas RALYL clinical characteristics prognosis
刊名ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
2012
DOI10.7314/APJCP.2012.13.7.3403
13期:7页:3403-3408
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GENE-EXPRESSION ; DNA MICROARRAY ; KIDNEY CANCER ; GROWTH ; SURVIVAL ; VHL ; CLASSIFICATION ; INHIBITION ; DISEASE ; VEGF
英文摘要

The molecular mechanisms involved in the progression of clear cell renal cell carcinomas (ccRCCs) are still unclear. The aim of this study was to analyse the relationships between expression of RALYL and clinical characteristics. In 41 paired samples of ccRCCs and adjacent normal tissues, we used real-time qPCR to evaluate the expression of RALYL mRNA. RALYL protein levels were determined in 146 samples of ccRCC and 37 adjacent normal tissues by immunohistochemistry. Statistical analysis was used to explore the relationships between expression of RALYL and the clinical characteristics (gender, age, tumor size, T stage, N stage, M stage, survival times and survival outcome) in ccRCC. In addition, these patients were follow-up period 64 months (range: 4 similar to 116months) to investigate the influence on prognosis. We found significantly differences between ccRCC tissues and normal tissues (p<0.001, paired-sample t test) in mRNA levels of RALYL. Immunohistochemistry analyses in 146 ccRCC samples and 37 adjacent normal tissues showed significantly lower RALYL protein levels in ccRCC samples (chi 2-test, p<0.001), inversely correlating with tumour size (p=0.024), T stage (0.005), N stage (p<0.001) as well as M stage (p=0.019), but not age (p=0.357) and gender (p=0.348). Kaplan-Meier survival analysis demonstrated that people with lower level of RALYL expression had a poorer survival rate than those with a higher level of RALYL expression, significantly different by the log-rank test (p=0.011). Cox regression analysis indicated that RALYL expression (p=0.039), N stage (p=0.008) and distant metastasis (p<0.001) were independent prognosis factors for the overall survival of ccRCC patients. We demonstrated that the expression of RALYL was significantly low in ccRCC and correlated with a poor prognosis in a large number of clinical samples. Our findings showed that RALYL may be a potential therapeutic target as well as a poor prognostic factor.

语种英语
WOS记录号WOS:000309476000066
项目编号201003099 ; CXB200903090055A ; CXB201005250016A ; CXB201005250017A ; CXC201005260001A ; 20100001110100
资助机构Science and Technology Program of Shenzhen ; Promotion Program for Shenzhen Key Laboratory ; Biobank of Complex Diseases in Shenzhen ; Doctoral Program Foundation of Ministry of Education of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59909
专题北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr,Inst Urol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen, Peoples R China
3.Shenzhen Second Peoples Hosp, Dept Urol, Shenzhen, Peoples R China
4.Shenzhen Univ, Inst Urogenital Dis, Shenzhen, Peoples R China
5.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen Key Lab Genitourinary Tumor, Shenzhen, Peoples R China
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Cui, Zhi-Wen,Xia, Ye,Ye, Yi-Wang,et al. RALY RNA Binding Protein-like Reduced Expression is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2012,13(7):3403-3408.
APA Cui, Zhi-Wen.,Xia, Ye.,Ye, Yi-Wang.,Jiang, Zhi-Mao.,Wang, Ya-Dong.,...&Cai, Zhi-Ming.(2012).RALY RNA Binding Protein-like Reduced Expression is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,13(7),3403-3408.
MLA Cui, Zhi-Wen,et al."RALY RNA Binding Protein-like Reduced Expression is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 13.7(2012):3403-3408.
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