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学科主题: 临床医学
题名:
RALY RNA Binding Protein-like Reduced Expression is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma
作者: Cui, Zhi-Wen1,2; Xia, Ye1,2; Ye, Yi-Wang1; Jiang, Zhi-Mao1; Wang, Ya-Dong1; Wu, Jian-Ting1; Sun, Liang3,4,5; Zhao, Jun1; Fa, Ping-Ping1; Sun, Xiao-Juan4,5; Gui, Yao-Ting1; Cai, Zhi-Ming1,3,4
关键词: Clear cell renal cell carcinomas ; RALYL ; clinical characteristics ; prognosis
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2012
DOI: 10.7314/APJCP.2012.13.7.3403
卷: 13, 期:7, 页:3403-3408
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GENE-EXPRESSION ; DNA MICROARRAY ; KIDNEY CANCER ; GROWTH ; SURVIVAL ; VHL ; CLASSIFICATION ; INHIBITION ; DISEASE ; VEGF
英文摘要:

The molecular mechanisms involved in the progression of clear cell renal cell carcinomas (ccRCCs) are still unclear. The aim of this study was to analyse the relationships between expression of RALYL and clinical characteristics. In 41 paired samples of ccRCCs and adjacent normal tissues, we used real-time qPCR to evaluate the expression of RALYL mRNA. RALYL protein levels were determined in 146 samples of ccRCC and 37 adjacent normal tissues by immunohistochemistry. Statistical analysis was used to explore the relationships between expression of RALYL and the clinical characteristics (gender, age, tumor size, T stage, N stage, M stage, survival times and survival outcome) in ccRCC. In addition, these patients were follow-up period 64 months (range: 4 similar to 116months) to investigate the influence on prognosis. We found significantly differences between ccRCC tissues and normal tissues (p<0.001, paired-sample t test) in mRNA levels of RALYL. Immunohistochemistry analyses in 146 ccRCC samples and 37 adjacent normal tissues showed significantly lower RALYL protein levels in ccRCC samples (chi 2-test, p<0.001), inversely correlating with tumour size (p=0.024), T stage (0.005), N stage (p<0.001) as well as M stage (p=0.019), but not age (p=0.357) and gender (p=0.348). Kaplan-Meier survival analysis demonstrated that people with lower level of RALYL expression had a poorer survival rate than those with a higher level of RALYL expression, significantly different by the log-rank test (p=0.011). Cox regression analysis indicated that RALYL expression (p=0.039), N stage (p=0.008) and distant metastasis (p<0.001) were independent prognosis factors for the overall survival of ccRCC patients. We demonstrated that the expression of RALYL was significantly low in ccRCC and correlated with a poor prognosis in a large number of clinical samples. Our findings showed that RALYL may be a potential therapeutic target as well as a poor prognostic factor.

语种: 英语
所属项目编号: 201003099 ; CXB200903090055A ; CXB201005250016A ; CXB201005250017A ; CXC201005260001A ; 20100001110100
项目资助者: Science and Technology Program of Shenzhen ; Promotion Program for Shenzhen Key Laboratory ; Biobank of Complex Diseases in Shenzhen ; Doctoral Program Foundation of Ministry of Education of China
WOS记录号: WOS:000309476000066
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59909
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen PKU HKUST Med Ctr,Inst Urol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen, Peoples R China
3.Shenzhen Second Peoples Hosp, Dept Urol, Shenzhen, Peoples R China
4.Shenzhen Univ, Inst Urogenital Dis, Shenzhen, Peoples R China
5.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen Key Lab Genitourinary Tumor, Shenzhen, Peoples R China

Recommended Citation:
Cui, Zhi-Wen,Xia, Ye,Ye, Yi-Wang,et al. RALY RNA Binding Protein-like Reduced Expression is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2012,13(7):3403-3408.
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