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学科主题: 临床医学
题名:
Narcolepsy Onset Is Seasonal and Increased following the 2009 H1N1 Pandemic in China
作者: Han, Fang1; Lin, Ling2; Warby, Simon C.2; Faraco, Juliette2; Li, Jing1; Dong, Song X.1; An, Pei1; Zhao, Long1; Wang, Ling H.1; Li, Qian Y.1; Yan, Han1; Gao, Zhan C.1; Yuan, Yuan1; Strohl, Kingman P.3,4; Mignot, Emmanuel2
刊名: ANNALS OF NEUROLOGY
发表日期: 2011-09-01
DOI: 10.1002/ana.22587
卷: 70, 期:3, 页:410-417
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CATAPLEXY ; AUTOANTIBODIES ; SUSCEPTIBILITY ; EPIDEMIOLOGY ; PREVALENCE ; INFLUENZA ; INFECTION ; CHILDREN ; DISEASE ; BIRTH
英文摘要:

Objective: Narcolepsy is caused by the loss of hypocretin/orexin neurons in the hypothalamus, which is likely the result of an autoimmune process. Recently, concern has been raised over reports of narcolepsy in northern Europe following H1N1 vaccination.

Methods: The study is a retrospective analysis of narcolepsy onset in subjects diagnosed in Beijing, China ( 19982010). Self-reported month and year of onset were collected from 629 patients (86% children). Graphical presentation, autocorrelations, chi-square, and Fourier analysis were used to assess monthly variation in onset. Finally, 182 patients having developed narcolepsy after October 2009 were asked for vaccination history.

Results: The occurrence of narcolepsy onset was seasonal, significantly influenced by month and calendar year. Onset was least frequent in November and most frequent in April, with a 6.7-fold increase from trough to peak. Studying year-to-year variation, we found a 3-fold increase in narcolepsy onset following the 2009 H1N1 winter influenza pandemic. The increase is unlikely to be explained by increased vaccination, as only 8 of 142 (5.6%) patients recalled receiving an H1N1 vaccination. Cross-correlation indicated a significant 5- to 7-month delay between the seasonal peak in influenza/cold or H1N1 infections and peak in narcolepsy onset occurrences.

Interpretation: In China, narcolepsy onset is highly correlated with seasonal and annual patterns of upper airway infections, including H1N1 influenza. In 2010, the peak seasonal onset of narcolepsy was phase delayed by 6 months relative to winter H1N1 infections, and the correlation was independent of H1N1 vaccination in the majority of the sample. ANN NEUROL 2011;70:410-417

语种: 英语
所属项目编号: 81070069 ; GZ538 ; D1011000050010029 ; NIH-NS23724
项目资助者: National Science Foundation of China ; Sino-German Center for Research Promotion ; Beijing Municipal Science and Technology Commission ; Veterans Administration Research Service
WOS记录号: WOS:000294816800014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59910
Appears in Collections:北京大学第二临床医学院_呼吸内科_期刊论文

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作者单位: 1.Beijing Univ, Peoples Hosp, Dept Pulm Med, Beijing 100044, Peoples R China
2.Stanford Ctr Sleep Sci & Med, Palo Alto, CA USA
3.Case Western Reserve Univ, Dept Med, Div Pulm Crit Care & Sleep Med, Cleveland, OH 44106 USA
4.Cleveland Louis Stokes Vet Adm Med Ctr, Cleveland, OH USA

Recommended Citation:
Han, Fang,Lin, Ling,Warby, Simon C.,et al. Narcolepsy Onset Is Seasonal and Increased following the 2009 H1N1 Pandemic in China[J]. ANNALS OF NEUROLOGY,2011,70(3):410-417.
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