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学科主题: 基础医学
题名:
Influence of acetazolamide on AQP1 gene expression in testis and on sperm count/motility in epididymis of rats
作者: Yu, HM; Sun, BM; Bai, Q; Koide, SS; Li, XJ
关键词: acetazolamide ; epididymis ; male reproductive tract ; sperm maturation ; sperm transport ; testis
刊名: ARCHIVES OF ANDROLOGY
发表日期: 2002-07-01
DOI: 10.1080/01485010290031592
卷: 48, 期:4, 页:281-294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: MALE REPRODUCTIVE-TRACT ; CARBONIC-ANHYDRASE ISOENZYMES ; CHIP28 WATER CHANNEL ; SEMINIFEROUS TUBULES ; XENOPUS OOCYTES ; CDNA CLONING ; LOCALIZATION ; PROTEIN ; AQUAPORIN-1 ; FLUID
英文摘要:

Acetazolamide (Ace) is a putative inhibitor of carbonic anhydrase (CA), an enzyme that catalyzes the equilibration of carbon dioxide and carbonic acid and plays a key role in HCO3- and water reabsorption and acid secretion. Aquaporins (AQPs) are channel-forming membrane glycoproteins that mediate water reabsorption by the renal tubules and other organs of mammals. AQP1 and CAII or CAIV share many common biological properties. Previous studies have shown that AQP1 and CA are located at the same sites in cells of the male reproductive tract. In the present study. Ace at a dose of 40 mg/kg/d x 14, administered per os, suppressed AQP1 gene expression and inhibited CA activity in rat testis. On day 7 of treatment the epididymal sperm motility was significantly reduced, while on day 14 a decrease in sperm count occurred. Ace caused a marked downregulation of AQP1 gene expression; significant suppression occurred on days 7 and 14. Moreover. CA activity was totally blocked throughout the treatment period. The present findings suggest that the reduction of rat sperm motility and count by Ace can be attributed to its capacity to downregulate AQP1 water channel gene expression.

语种: 英语
WOS记录号: WOS:000176364500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59914
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Populat Council, Ctr Biomed Res, New York, NY 10021 USA
2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
3.Natl Res Inst Family Planning, Beijing, Peoples R China

Recommended Citation:
Yu, HM,Sun, BM,Bai, Q,et al. Influence of acetazolamide on AQP1 gene expression in testis and on sperm count/motility in epididymis of rats[J]. ARCHIVES OF ANDROLOGY,2002,48(4):281-294.
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