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学科主题: 药学
题名:
Sustained release of cisplatin from multivesicular liposomes: Potentiation of antitumor efficacy against S180 murine carcinoma
作者: Xiao, CJ; Qi, XR; Maitani, Y; Nagai, T
关键词: cisplatin ; multivesicular liposomes ; S180 tumor ; sustained release ; pharmacokinetics ; therapeutic efficacy
刊名: JOURNAL OF PHARMACEUTICAL SCIENCES
发表日期: 2004-07-01
DOI: 10.1002/jps.20086
卷: 93, 期:7, 页:1718-1724
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: SOYBEAN-DERIVED STEROLS ; COMPARATIVE PHARMACOKINETICS ; MICE ; NEPHROTOXICITY ; TECHNOLOGY ; DELIVERY ; RATS
英文摘要:

Cisplatin was encapsulated into multivesicular liposomes (MVLs) and the entrapment efficiency, size distribution, and in vitro drug release characteristics of the cisplatin-MVLs were studied. Pharmacokinetics, tissue distribution, and therapeutic efficacy of cisplatin-MVLs were compared against injection of cisplatin solution into mice inoculated with the murine carcinoma 180 (S180) tumor. The results showed that the cisplatin-MVLs were capable of high drug loading (0.1.48:1 mg cisplatin/mg lipid) and high encapsulation efficiency (>80%). The mean diameter of cisplatin-MVLs was 17 pm. In vitro studies of cisplatin-MVLs in saline solution showed that they sustained release of encapsulated drug for >7 days. Cisplatin-MVLs showed higher drug accumulation in the liver, spleen, and tumor regions than cisplatin solution, as well as higher plasma concentrations and a longer circulation time. The therapeutic efficacy of the cisplatin-MVL preparation against S180 tumor-bearing mice is significantly higher than that of cisplatin solution. (C) 2004 Wiley-Liss, Inc. and the American Pharmacists Association.

语种: 英语
WOS记录号: WOS:000222315300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59915
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 1428501, Japan
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Xiao, CJ,Qi, XR,Maitani, Y,et al. Sustained release of cisplatin from multivesicular liposomes: Potentiation of antitumor efficacy against S180 murine carcinoma[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2004,93(7):1718-1724.
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