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Sustained release of cisplatin from multivesicular liposomes: Potentiation of antitumor efficacy against S180 murine carcinoma
Xiao, CJ; Qi, XR; Maitani, Y; Nagai, T
关键词cisplatin multivesicular liposomes S180 tumor sustained release pharmacokinetics therapeutic efficacy
刊名JOURNAL OF PHARMACEUTICAL SCIENCES
2004-07-01
DOI10.1002/jps.20086
93期:7页:1718-1724
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]SOYBEAN-DERIVED STEROLS ; COMPARATIVE PHARMACOKINETICS ; MICE ; NEPHROTOXICITY ; TECHNOLOGY ; DELIVERY ; RATS
英文摘要

Cisplatin was encapsulated into multivesicular liposomes (MVLs) and the entrapment efficiency, size distribution, and in vitro drug release characteristics of the cisplatin-MVLs were studied. Pharmacokinetics, tissue distribution, and therapeutic efficacy of cisplatin-MVLs were compared against injection of cisplatin solution into mice inoculated with the murine carcinoma 180 (S180) tumor. The results showed that the cisplatin-MVLs were capable of high drug loading (0.1.48:1 mg cisplatin/mg lipid) and high encapsulation efficiency (>80%). The mean diameter of cisplatin-MVLs was 17 pm. In vitro studies of cisplatin-MVLs in saline solution showed that they sustained release of encapsulated drug for >7 days. Cisplatin-MVLs showed higher drug accumulation in the liver, spleen, and tumor regions than cisplatin solution, as well as higher plasma concentrations and a longer circulation time. The therapeutic efficacy of the cisplatin-MVL preparation against S180 tumor-bearing mice is significantly higher than that of cisplatin solution. (C) 2004 Wiley-Liss, Inc. and the American Pharmacists Association.

语种英语
WOS记录号WOS:000222315300006
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59915
专题北京大学药学院_药剂学系
作者单位1.Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 1428501, Japan
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
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GB/T 7714
Xiao, CJ,Qi, XR,Maitani, Y,et al. Sustained release of cisplatin from multivesicular liposomes: Potentiation of antitumor efficacy against S180 murine carcinoma[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2004,93(7):1718-1724.
APA Xiao, CJ,Qi, XR,Maitani, Y,&Nagai, T.(2004).Sustained release of cisplatin from multivesicular liposomes: Potentiation of antitumor efficacy against S180 murine carcinoma.JOURNAL OF PHARMACEUTICAL SCIENCES,93(7),1718-1724.
MLA Xiao, CJ,et al."Sustained release of cisplatin from multivesicular liposomes: Potentiation of antitumor efficacy against S180 murine carcinoma".JOURNAL OF PHARMACEUTICAL SCIENCES 93.7(2004):1718-1724.
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