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Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation
Ning, Xianling1; Guo, Ying1; Ma, Xiaoyan1; Zhu, Renzong1; Tian, Chao1; Wang, Xiaowei1; Ma, Zhizhong3; Zhang, Zhili1; Liu, Junyi1,2
关键词E-3,4-Dihydroxy styryl aralkyl ketones Caffeic acid phenethyl ester Neuroprotective agents Antioxidants Anti-inflammatory
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2013-07-01
DOI10.1016/j.bmcl.2013.05.016
23期:13页:3700-3703
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ACID PHENETHYL ESTER ; FACTOR-KAPPA-B ; HYDROGEN-PEROXIDE ; ANTIOXIDANT PROPERTIES ; CELLS ; BRAIN ; INHIBITOR ; APOPTOSIS ; INJURY ; CYCLOOXYGENASE-2
英文摘要

E-3,4-Dihydroxy styryl aralkyl ketones as well as their 3,4-diacetylated derivatives as the analogues of neuroprotective agent CAPE were designed and synthesized for improving stability and lipid solubility. The neuroprotective activities of target compounds 10a-g and 11a-g were tested by three models in vitro, including 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity, neuronal protecting effect against damage induced by H2O2 in PC12 cells and nitric oxide suppression effect in BV2 microglial cells. The results demonstrated that compounds 10f and 11f exhibited the most potent neuroprotective effect against oxidative stress and inflammation, which is higher than that of the lead compound CAPE. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号20972011 ; 21042009 ; 21172014 ; 2009ZX09301-010
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号WOS:000320702900003
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59916
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ning, Xianling,Guo, Ying,Ma, Xiaoyan,et al. Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(13):3700-3703.
APA Ning, Xianling.,Guo, Ying.,Ma, Xiaoyan.,Zhu, Renzong.,Tian, Chao.,...&Liu, Junyi.(2013).Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(13),3700-3703.
MLA Ning, Xianling,et al."Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.13(2013):3700-3703.
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