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学科主题临床医学
Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma
Krejsgaard, Thorbjorn1; Litvinov, Ivan V.2; Wang, Yang3,4; Xia, Lixin3,5; Willerslev-Olsen, Andreas1; Koralov, Sergei B.6; Kopp, Katharina L.1; Bonefeld, Charlotte M.1; Wasik, Mariusz A.7; Geisler, Carsten1; Woetmann, Anders1; Zhou, Youwen3; Sasseville, Denis2; Odum, Niels1
刊名BLOOD
2013-08-08
DOI10.1182/blood-2013-01-480889
122期:6页:943-950
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]MYCOSIS-FUNGOIDES ; SEZARY-SYNDROME ; GROWTH-FACTOR ; EPIDERMAL HYPERPLASIA ; INTERNATIONAL-SOCIETY ; PROGNOSTIC-FACTORS ; EXPRESSION ; RECEPTOR ; IL-17 ; ANGIOGENESIS
英文摘要

Inappropriately regulated expression of interleukin (IL)-17A is associated with the development of inflammatory diseases and cancer. However, little is known about the role of other IL-17 family members in carcinogenesis. Here, we show that a set of malignant T-cell lines established from patients with cutaneous T-cell lymphoma (CTCL) spontaneously secrete IL-17F and that inhibitors of Janus kinases and Signal transducer and activator of transcription 3 are able to block that secretion. Other malignant T-cell lines produce IL-17A but not IL-17F. Upon activation, however, some of the malignant T-cell lines are able to coexpress IL-17A and IL-17F, leading to formation of IL-17A/F heterodimers. Clinically, we demonstrate that IL-17F messenger RNA expression is significantly increased in CTCL skin lesions compared with healthy donors and patients with chronic dermatitis. IL-17A expression is also increased and a significant number of patients express high levels of both IL-17A and IL-17F. Concomitantly, we observed that the expression of the IL-17 receptor is significantly increased in CTCL skin lesions compared with control subjects. Importantly, analysis of a historic cohort of 60 CTCL patients indicates that IL-17F expression is associated with progressive disease. These findings implicate IL-17F in the pathogenesis of CTCL and suggest that IL-17 cytokines and their receptors may serve as therapeutic targets.

语种英语
WOS记录号WOS:000322879100017
项目编号CA89194
资助机构Carlsberg Foundation ; Danish Cancer Society ; Dansk Kraeftforsknings Fond ; Danish Research Councils ; Danish National Advanced Technology Foundation ; Copenhagen Cluster of Immunology ; Lundbeck Foundation ; Novo Nordic Foundation ; Beckett Foundation (Beckett-Fonden) ; University of Copenhagen ; National Cancer Institute ; Canadian Dermatology Foundation ; Fonds de recherche du Quebec-Sante
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59917
专题北京大学第一临床医学院
作者单位1.McGill Univ, Div Dermatol, Ctr Hlth, Montreal, PQ, Canada
2.NYU, Dept Pathol, Langone Med Ctr, New York, NY 10016 USA
3.Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA
4.Univ Copenhagen, Dept Int Hlth Immunol & Microbiol, DK-2200 Copenhagen N, Denmark
5.Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 4E8, Canada
6.Peking Univ, Dept Dermatol & Venerol, Hosp 1, Beijing 100871, Peoples R China
7.China Med Univ, Dept Dermatol, Hosp 1, Shenyang, Peoples R China
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GB/T 7714
Krejsgaard, Thorbjorn,Litvinov, Ivan V.,Wang, Yang,et al. Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma[J]. BLOOD,2013,122(6):943-950.
APA Krejsgaard, Thorbjorn.,Litvinov, Ivan V..,Wang, Yang.,Xia, Lixin.,Willerslev-Olsen, Andreas.,...&Odum, Niels.(2013).Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma.BLOOD,122(6),943-950.
MLA Krejsgaard, Thorbjorn,et al."Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma".BLOOD 122.6(2013):943-950.
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