IR@PKUHSC  > 北京大学药学院
学科主题药学
CsOH catalyzed aerobic oxidative synthesis of p-quinols from multi-alkyl phenols under mild conditions
Liang, Yu-Feng1,2; Wu, Kai1,2; Liu, Zhiqing3; Wang, Xiaoyang1,2; Liang, Yujie1,2; Liu, Chenjiang3; Jiao, Ning1,2
关键词P-quinol Molecular Oxygen De-aromatization Carbanion Cesium Hydroxide
刊名SCIENCE CHINA-CHEMISTRY
2015-08-01
DOI10.1007/s11426-015-5363-4
58期:8页:1334-1339
收录类别SCI ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]Hypervalent Iodine Oxidation ; h Bond Functionalization ; 4-iodophenoxyacetic Acid ; Substituted Phenols ; Therapeutic Agents ; Organic-synthesis ; Molecular-oxygen ; Singlet Oxygen ; Cleavage ; Derivatives
英文摘要

p-Quinols are ubiquitous structural motifs of various natural products and pharmaceutical compounds, and versatile building blocks in synthetic chemistry. The reported methods for the synthesis of p-quinol require stoichiometric amounts of oxidants. Molecular oxygen is considered as an ideal oxidant due to its natural, inexpensive, and environmentally friendly characteristics. During the ongoing research of C-H bond hydroxylation, we found that multi-alkyl phenols could react with molecular oxygen under mild conditions. Herein, we describe an efficient oxidative de-aromatization of multi-alkyl phenols to p-quinols. 1 atm of molecular oxygen was used as the oxidant. Many multi-alkyl phenols could react smoothly at room temperature. Isotopic labeling experiment was also performed, and the result proved that the oxygen atom in the produced hydroxyl group is from molecular oxygen.

语种英语
WOS记录号WOS:000358605500015
通讯作者邮箱pxylcj@126.com
项目编号21325206 ; 21172006 ; XJDX0908-2013-2
资助机构National Natural Science Foundation of China ; Key Laboratory of Oil and Gas Fine Chemicals
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59920
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Xinjiang Univ, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uygur Autonomous Reg, Urumqi 830046, Peoples R China
推荐引用方式
GB/T 7714
Liang, Yu-Feng,Wu, Kai,Liu, Zhiqing,et al. CsOH catalyzed aerobic oxidative synthesis of p-quinols from multi-alkyl phenols under mild conditions[J]. SCIENCE CHINA-CHEMISTRY,2015,58(8):1334-1339.
APA Liang, Yu-Feng.,Wu, Kai.,Liu, Zhiqing.,Wang, Xiaoyang.,Liang, Yujie.,...&Jiao, Ning.(2015).CsOH catalyzed aerobic oxidative synthesis of p-quinols from multi-alkyl phenols under mild conditions.SCIENCE CHINA-CHEMISTRY,58(8),1334-1339.
MLA Liang, Yu-Feng,et al."CsOH catalyzed aerobic oxidative synthesis of p-quinols from multi-alkyl phenols under mild conditions".SCIENCE CHINA-CHEMISTRY 58.8(2015):1334-1339.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liang, Yu-Feng]的文章
[Wu, Kai]的文章
[Liu, Zhiqing]的文章
百度学术
百度学术中相似的文章
[Liang, Yu-Feng]的文章
[Wu, Kai]的文章
[Liu, Zhiqing]的文章
必应学术
必应学术中相似的文章
[Liang, Yu-Feng]的文章
[Wu, Kai]的文章
[Liu, Zhiqing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。