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学科主题: 临床医学
题名:
Long-term effects of neonatal seizures on subsequent N-methyl-D-aspartate receptor-1 and gamma-aminobutyric acid receptor A-alpha 1 receptor expression in hippocampus of the Wistar rat
作者: Ni, H; Jiang, YW; Bo, T; Wang, JM; Pan, H; Wu, XR
关键词: neonatal seizures ; seizure-induced brain injury ; receptor ; NMDA ; GABA-A-alpha 1
刊名: NEUROSCIENCE LETTERS
发表日期: 2004-09-30
DOI: 10.1016/j.neulet.2004.05.008
卷: 368, 期:3, 页:254-257
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: GABA(A) RECEPTORS ; DEVELOPING BRAIN ; EPILEPSY
英文摘要:

To evaluate the pathophysiological mechanism of subsequent reduced seizure threshold following neonatal seizures, single or recurrent prolonged seizures were induced to neonatal rats by the inhalant flurothyl. The expression of N-methyl-D-aspartate receptor 1 (NR1) and gamma-aminobutyric acid receptor A-alpha1 (GABA-A-alpha1) immunoreactivity in hippocampus were examined by Western blotting analysis at the day 7 (P7) and day 75 (P75) after the last seizure. Whereas there were no significant changes in single seizure group and recurrent seizure group of P75, NR1 expression enhanced significantly in P7 rats of recurrent seizure group. Meanwhile, polypeptide levels of GABA-A-alpha1 receptor subunit decreased significantly in both single and recurrent seizure-treated P7 and P75 rats. Our results suggest that recurrent or single prolonged seizures during the neonatal period may have long-term effects on the balance between excitatory NMDA system and inhibitory GABA system in hippocampus of rats. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000224288700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59923
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Ni, H,Jiang, YW,Bo, T,et al. Long-term effects of neonatal seizures on subsequent N-methyl-D-aspartate receptor-1 and gamma-aminobutyric acid receptor A-alpha 1 receptor expression in hippocampus of the Wistar rat[J]. NEUROSCIENCE LETTERS,2004,368(3):254-257.
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