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Long-term effects of neonatal seizures on subsequent N-methyl-D-aspartate receptor-1 and gamma-aminobutyric acid receptor A-alpha 1 receptor expression in hippocampus of the Wistar rat
Ni, H; Jiang, YW; Bo, T; Wang, JM; Pan, H; Wu, XR
关键词neonatal seizures seizure-induced brain injury receptor NMDA GABA-A-alpha 1
刊名NEUROSCIENCE LETTERS
2004-09-30
DOI10.1016/j.neulet.2004.05.008
368期:3页:254-257
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]GABA(A) RECEPTORS ; DEVELOPING BRAIN ; EPILEPSY
英文摘要

To evaluate the pathophysiological mechanism of subsequent reduced seizure threshold following neonatal seizures, single or recurrent prolonged seizures were induced to neonatal rats by the inhalant flurothyl. The expression of N-methyl-D-aspartate receptor 1 (NR1) and gamma-aminobutyric acid receptor A-alpha1 (GABA-A-alpha1) immunoreactivity in hippocampus were examined by Western blotting analysis at the day 7 (P7) and day 75 (P75) after the last seizure. Whereas there were no significant changes in single seizure group and recurrent seizure group of P75, NR1 expression enhanced significantly in P7 rats of recurrent seizure group. Meanwhile, polypeptide levels of GABA-A-alpha1 receptor subunit decreased significantly in both single and recurrent seizure-treated P7 and P75 rats. Our results suggest that recurrent or single prolonged seizures during the neonatal period may have long-term effects on the balance between excitatory NMDA system and inhibitory GABA system in hippocampus of rats. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000224288700003
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59923
专题北京大学第一临床医学院_儿科
作者单位Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Ni, H,Jiang, YW,Bo, T,et al. Long-term effects of neonatal seizures on subsequent N-methyl-D-aspartate receptor-1 and gamma-aminobutyric acid receptor A-alpha 1 receptor expression in hippocampus of the Wistar rat[J]. NEUROSCIENCE LETTERS,2004,368(3):254-257.
APA Ni, H,Jiang, YW,Bo, T,Wang, JM,Pan, H,&Wu, XR.(2004).Long-term effects of neonatal seizures on subsequent N-methyl-D-aspartate receptor-1 and gamma-aminobutyric acid receptor A-alpha 1 receptor expression in hippocampus of the Wistar rat.NEUROSCIENCE LETTERS,368(3),254-257.
MLA Ni, H,et al."Long-term effects of neonatal seizures on subsequent N-methyl-D-aspartate receptor-1 and gamma-aminobutyric acid receptor A-alpha 1 receptor expression in hippocampus of the Wistar rat".NEUROSCIENCE LETTERS 368.3(2004):254-257.
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