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学科主题: 基础医学
题名:
Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans
作者: Duan, XZ; Wang, M; Li, HW; Zhuang, H; Xu, DP; Wang, FS
关键词: chronic hepatitis ; dendritic cells ; liver cirrhosis ; nosocomial infections
刊名: JOURNAL OF CLINICAL IMMUNOLOGY
发表日期: 2004-11-01
卷: 24, 期:6, 页:637-646
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: INTERFERON-PRODUCING CELLS ; PERIPHERAL-BLOOD ; IMMUNE-RESPONSE ; HEPATOCELLULAR-CARCINOMA ; LAMIVUDINE TREATMENT ; ADAPTIVE IMMUNITY ; IMPAIRED FUNCTION ; VIRAL-INFECTIONS ; T-CELLS ; INNATE
英文摘要:

The Type 2 precusor plasmacytoid dendritic cells (pDC) represent the most important cell type in antiviral innate immunity. To understand the function of pDC during hepatitis B virus infection, the frequency and function of circulating pDC were analyzed by flow cytometric analysis, and IFN-alpha secretion of total PBMCs was determined by ELISA assay in 25 healthy subjects and 116 patients at various stages of chronic hepatitis B virus infection (CHB). The number of circulating pDC was found to be significantly lower in patients with CHB and associated liver cirrhosis (LC). The ability of PBMCs to secrete IFN-alpha also decreased significantly. There was a corresponding decrease of circulating NK cells and CD8(+) T cells. We observed that lamuvidine antiviral therapy restored the number of circulating pDC and there was a reversal of pDC frequency with the control of HBV replication in chronic HBV patients, indicating these subjects are unlikely to be totally immunecompromised. The decrease of pDC was found to be related to nosocomial infections in LC patients. Our results suggest that CHB patients probably have a quantitative and qualitative impairment of circulating pDC or NK cells, which may be associated with HBV persistent infection as well as the nosocomial infections that arise in LC patients.

语种: 英语
WOS记录号: WOS:000225962800007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59929
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Beijing 302 Hosp, Beijing Inst Infect Dis, Res Ctr Biol Therapy, Beijing 100039, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China

Recommended Citation:
Duan, XZ,Wang, M,Li, HW,et al. Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2004,24(6):637-646.
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