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学科主题基础医学
Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans
Duan, XZ; Wang, M; Li, HW; Zhuang, H; Xu, DP; Wang, FS
关键词chronic hepatitis dendritic cells liver cirrhosis nosocomial infections
刊名JOURNAL OF CLINICAL IMMUNOLOGY
2004-11-01
24期:6页:637-646
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]INTERFERON-PRODUCING CELLS ; PERIPHERAL-BLOOD ; IMMUNE-RESPONSE ; HEPATOCELLULAR-CARCINOMA ; LAMIVUDINE TREATMENT ; ADAPTIVE IMMUNITY ; IMPAIRED FUNCTION ; VIRAL-INFECTIONS ; T-CELLS ; INNATE
英文摘要

The Type 2 precusor plasmacytoid dendritic cells (pDC) represent the most important cell type in antiviral innate immunity. To understand the function of pDC during hepatitis B virus infection, the frequency and function of circulating pDC were analyzed by flow cytometric analysis, and IFN-alpha secretion of total PBMCs was determined by ELISA assay in 25 healthy subjects and 116 patients at various stages of chronic hepatitis B virus infection (CHB). The number of circulating pDC was found to be significantly lower in patients with CHB and associated liver cirrhosis (LC). The ability of PBMCs to secrete IFN-alpha also decreased significantly. There was a corresponding decrease of circulating NK cells and CD8(+) T cells. We observed that lamuvidine antiviral therapy restored the number of circulating pDC and there was a reversal of pDC frequency with the control of HBV replication in chronic HBV patients, indicating these subjects are unlikely to be totally immunecompromised. The decrease of pDC was found to be related to nosocomial infections in LC patients. Our results suggest that CHB patients probably have a quantitative and qualitative impairment of circulating pDC or NK cells, which may be associated with HBV persistent infection as well as the nosocomial infections that arise in LC patients.

语种英语
WOS记录号WOS:000225962800007
引用统计
被引频次:76[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59929
专题北京大学基础医学院_病原生物学系
作者单位1.Beijing 302 Hosp, Beijing Inst Infect Dis, Res Ctr Biol Therapy, Beijing 100039, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
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GB/T 7714
Duan, XZ,Wang, M,Li, HW,et al. Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2004,24(6):637-646.
APA Duan, XZ,Wang, M,Li, HW,Zhuang, H,Xu, DP,&Wang, FS.(2004).Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans.JOURNAL OF CLINICAL IMMUNOLOGY,24(6),637-646.
MLA Duan, XZ,et al."Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans".JOURNAL OF CLINICAL IMMUNOLOGY 24.6(2004):637-646.
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