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学科主题临床医学
Common underlying diseases do not contribute in determining the causes of sudden unexplained death
Tian Zhao-xing1; Lu Yan-yu4; Nugessur, Chetan Rai2; Yan Wei3; Zhao Wen-kui1; Kong Li-li1; Zheng Ya-an1
关键词Sudden Unexplained Death Common Underlying Diseases Death Causes
刊名CHINESE MEDICAL JOURNAL
2013-03-05
DOI10.3760/cma.j.issn.0366-6999.20121226
126期:5页:870-874
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]EARLY REPOLARIZATION ; CARDIAC DEATH ; YOUNG-ADULTS ; GENE ; CARDIOMYOPATHY ; MALFORMATIONS ; MUTATION ; CHILDREN
英文摘要

Background Underlying diseases have a statistically significant positive correlation to sudden death. However, sudden unexplained death (SUD) is different from sudden death, as there is no clinical evidence to support the sudden death due to the original underlying disease, nor a lethal pathological basis to be found during autopsy. In addition, SUD are more common in young, previously healthy individuals, usually without any signs of disease, with no positive lesions found after autopsy. Therefore, a causal relationship between SUD and the underlying disease needs to be further explored. This study aimed to explore the role that common underlying diseases play in patients with SUD and to reveal the correlation between them.

Methods The medical records, history and case information of 208 patients with SUD were collected for the survey. All these SUD occurred in the emergency room of Peking University Third Hospital from January 2006 to December 2009. The patients were stratified by with and without common underlying diseases. To examine possible associations between the underlying diseases and the cause of unexplained sudden death, the chi-squared and Fisher′s exact tests were used.

Results Among the 208 patients, 65 were diagnosed with common underlying diseases while 143 were not. Within these two groups, there were 45 patients for whom the clear cause of death was determined. However, there were no statistically significant differences or strong associations (x(2)=1.238, P >0.05) between the 11 patients with (16.90%) and 34 without (23.78%) common underlying disease among these 45 patients. We also found that occurrence of the common underlying diseases, such as neurological system, cardiovascular and pulmonary system diseases, are not statistically significant (P >0.05) in the diagnosis of the SUD.

Conclusion Common underlying diseases make no obvious contributions to SUD and are not useful in diagnosing the underlying reasons for death.

语种英语
所属项目编号81172745
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000319783500014
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59932
专题北京大学第三临床医学院_急诊科
作者单位1.Peking Univ, Hosp 3, Dept Emergency Med, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Gastroenterol & Hepatol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Resp Dis, Beijing 100191, Peoples R China
4.Capital Inst Pediat, Beijing 100020, Peoples R China
推荐引用方式
GB/T 7714
Tian Zhao-xing,Lu Yan-yu,Nugessur, Chetan Rai,et al. Common underlying diseases do not contribute in determining the causes of sudden unexplained death[J]. CHINESE MEDICAL JOURNAL,2013,126(5):870-874.
APA Tian Zhao-xing.,Lu Yan-yu.,Nugessur, Chetan Rai.,Yan Wei.,Zhao Wen-kui.,...&Zheng Ya-an.(2013).Common underlying diseases do not contribute in determining the causes of sudden unexplained death.CHINESE MEDICAL JOURNAL,126(5),870-874.
MLA Tian Zhao-xing,et al."Common underlying diseases do not contribute in determining the causes of sudden unexplained death".CHINESE MEDICAL JOURNAL 126.5(2013):870-874.
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