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学科主题: 药学
题名:
New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells
作者: Deng, Gai-Gai1; Wei, Wei1; Yang, Xiu-Wei1; Zhang, You-Bo1; Xu, Wei1; Gong, Ning-Bo2; Lu, Yang2; Wang, Feng-Feng2
关键词: Angelica dahurica var. formosana cv. ; Chuanbaizhi ; Coumarins ; (-)-Hydroxydecursinol ; (+/-)-Dahuribiscoumarin ; Nitric oxide ; Inducible nitric oxide synthase
刊名: FITOTERAPIA
发表日期: 2015-03-01
DOI: 10.1016/j.fitote.2015.01.016
卷: 101, 页:194-200
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE PRODUCTION ; GLEHNIA-LITTORALIS ; MYRISTICA-FRAGRANS ; ENDOTHELIAL-CELLS ; IN-VITRO ; IMPERATORIN ; EXPRESSION ; ISOIMPERATORIN ; PHELLOPTERIN ; PATHWAYS
英文摘要:

A new linear pyranocoumarin named (-)-hydroxydecursinol (1) and a new biscoumarin named (+/-)-dahuribiscoumarin (2), together with six known compounds isoimperatorin (3), imperatorin (4), phellopterin (5), isodemethylfuropinarine (6), demethylfuropinarine (7), and (+)-decursinol (8) were isolated from the 75% ethanolic extract of the roots of Angelica dahurica var. formosana cv. Chuanbaizhi. Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry, and the structure of 2 was confirmed by single-crystal X-ray diffraction. All of the isolated compounds were evaluated for the inhibition against nitric oxide (NO) production in the lipopolysaccharide (LPS)-activated RAW264.7 macrophage cell line, and exhibited the inhibitory activity on NO production in a concentration-dependent manner. Furthermore, real-time PCR analysis revealed that compounds 2, 5-8 could significantly suppress the expression levels of inducible nitric oxide synthase mRNA in a concentration-dependent manner. And their primary structure-activity relationships of NO inhibitory effects were also briefly discussed. These compounds are potential candidates for further bioassay studies to determine their suitability as drug leads. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81473321 ; 7152086 ; 2011BAI07B08
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; National Key Technology R &amp ; D Program of China
WOS记录号: WOS:000352252700024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59935
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs,Dept Nat Med, Beijing 100191, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

Recommended Citation:
Deng, Gai-Gai,Wei, Wei,Yang, Xiu-Wei,et al. New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells[J]. FITOTERAPIA,2015,101:194-200.
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