学科主题基础医学
Immunoglobulin gene locus events in epithelial cells of lactating mouse mammary glands
Zhang, Shuai1; Mao, Yuntao1; Huang, Jing1; Ma, Teng1; Zhang, Li1; Zhu, Xiaohui1; Zheng, Jie1; Wu, Lemeng1; Yin, C. Cameron2; Qiu, Xiaoyan1,2
关键词Immunoglobulin Colostrum Mammary gland epithelial cells
刊名CELLULAR AND MOLECULAR LIFE SCIENCES
2010-03-01
DOI10.1007/s00018-009-0231-z
67期:6页:985-994
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
资助者Natural Sciences Foundation, China ; Natural Sciences Foundation, China
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]FC-RECEPTOR ; EXPRESSION ; MILK ; AID
英文摘要

It has been believed that the immunoglobulin (Ig) found abundantly in the colostrum of lactating mammalian is derived from serum or secreted by plasma cells present in the mammary gland. The recent finding of Ig gene rearrangements in breast cancer cells and benign hyperplastic breast epithelial cells suggests that it is likely that hyperplastic mammary gland epithelial cells during lactation can also produce Ig. In this study, we have demonstrated the presence of abundant amounts of Ig heavy and light chain transcripts in sorted cytokeratin 18-positive mammary gland epithelial cells of lactating mice. Interestingly, we found two specific Ig kappa variable region sequences (V(CW9)J(kappa 1) and V(BV9)J(kappa 1)) that were dominantly expressed in different strains of mice. Our data demonstrate that IgG is expressed by mammary gland epithelial cells of lactating mice, and suggest that the IgG found in murine colostrum is at least partially produced by the mammary gland epithelial cells.

语种英语
所属项目编号30572094 ; 30772470
资助者Natural Sciences Foundation, China ; Natural Sciences Foundation, China
WOS记录号WOS:000274903200012
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59937
专题北京大学基础医学院_北京大学人类疾病基因研究中心
作者单位1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Zhang, Shuai,Mao, Yuntao,Huang, Jing,et al. Immunoglobulin gene locus events in epithelial cells of lactating mouse mammary glands[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2010,67(6):985-994.
APA Zhang, Shuai.,Mao, Yuntao.,Huang, Jing.,Ma, Teng.,Zhang, Li.,...&Qiu, Xiaoyan.(2010).Immunoglobulin gene locus events in epithelial cells of lactating mouse mammary glands.CELLULAR AND MOLECULAR LIFE SCIENCES,67(6),985-994.
MLA Zhang, Shuai,et al."Immunoglobulin gene locus events in epithelial cells of lactating mouse mammary glands".CELLULAR AND MOLECULAR LIFE SCIENCES 67.6(2010):985-994.
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