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学科主题: 临床医学
题名:
The antiallodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability in rats with spared nerve injury
作者: Ding, Lei1; Cai, Jie2,3,4,5; Guo, Xiang-Yang1; Meng, Xiu-Li1; Xing, Guo-Gang2,3,4,5
关键词: Electrophysiology ; Neuropathic pain ; Pregabalin ; Spinal dorsal horn ; WDR neurons
刊名: PAIN RESEARCH & MANAGEMENT
发表日期: 2014-07-01
卷: 19, 期:4, 页:205-211
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PERIPHERAL NEUROPATHIC PAIN ; BONE CANCER PAIN ; NR2B-CONTAINING NMDA RECEPTORS ; ROOT GANGLION NEURONS ; DORSAL-HORN ; CENTRAL SENSITIZATION ; ALPHA(2)DELTA-1 SUBUNIT ; ALPHA(2)-DELTA SUBUNIT ; POSTHERPETIC NEURALGIA ; NEOCORTICAL SLICES
英文摘要:

BACKGROUND: Pregabalin (PGB) is a novel antiepileptic drug and is also used as a first-line medication for the treatment of neuropathic pain. However, the mechanisms of its analgesic effects remain largely unknown.

OBJECTIVES: To elucidate the mechanisms underlying the antiallodynic action of PGB in rats with neuropathic pain.

METHODS: In a rat model of neuropathic pain induced by spared nerve injury, mechanical allodynia, as a behavioural sign of neuropathic pain, was assessed by measuring 50% paw withdrawal threshold with von Frey filaments. Activities of dorsal horn wide dynamic range (WDR) neurons were examined by extracellular electrophysiological recording in vivo.

RESULTS : Spinal administration of PGB exerted a significant antiallodynic effect and a prominent inhibitory effect on the hypersensitivity of dorsal horn WDR neurons in rats with spared nerve injury.

CONCLUSION: The antiallodynic action of PGB is likely dependent on the suppression of WDR neuron hyperexcitability in rats with neuropathic pain.

语种: 英语
所属项目编号: 81371237 ; 31171063 ; 61027001 ; 2013CB531905
项目资助者: National Natural Science Foundation of China ; &prime ; 973&prime ; Program of the Ministry of Science and Technology of China
WOS记录号: WOS:000340463500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59938
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

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作者单位: 1.Peking Univ, Dept Neurobiol, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
3.Minist Publ Hlth, Beijing, Peoples R China
4.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
5.Peking Univ, Dept Anesthesiol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Ding, Lei,Cai, Jie,Guo, Xiang-Yang,et al. The antiallodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability in rats with spared nerve injury[J]. PAIN RESEARCH & MANAGEMENT,2014,19(4):205-211.
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