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学科主题: 药学
题名:
Identification and determination of major flavonoids in rat urine by HPLC-UV and HPLC-MS methods following oral administration of Dalbergia odorifera extract
作者: Liu, RX; Wang, W; Wang, Q; Bi, KS; Guo, D
关键词: Dalbergia odorifera ; flavonoids ; (3R)4 &prime ; -methoxy-2 &prime ; ,3,7-trihydroxyisoflavanone ; vestitone ; urine
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2006
DOI: 10.1002/bmc.535
卷: 20, 期:1, 页:101-108
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; HUMAN PLASMA ; ARRAY ; CONSTITUENTS ; BUTEIN
英文摘要:

Flavonoids are the main active constituents of Dalbergia odorifera. The excretion of the major flavonoids in rat urine after oral administration of D. odorifera extract was investigated by HPLC-UV and HPLC-MS methods. Utilizing the HPLC-MS technique, 18 flavonoids, including five isoflavones, four isoflavanones, four neoflavones, two flavanones, two chalcones and one isoflavanonol were identified in free form in a urine sample based on the direct comparison of the corresponding t(R), UV maximum absorbance (lambda(max)) values and MS data with the authentic standards. The amounts of the prominent flavonoids, (3R)-4′-methoxy-2′,3,7-trihydroxyisoflavanone and vestitone, were determined by HPLC-UV with the internal standard method, and the validation procedure confirmed that it afforded reliable analysis of these two analytes in urine after oral administration of D. odorifera extract. Copyright (c) 2005 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000234871800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59941
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
3.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China

Recommended Citation:
Liu, RX,Wang, W,Wang, Q,et al. Identification and determination of major flavonoids in rat urine by HPLC-UV and HPLC-MS methods following oral administration of Dalbergia odorifera extract[J]. BIOMEDICAL CHROMATOGRAPHY,2006,20(1):101-108.
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