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学科主题基础医学
Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain
Huang, C; Hu, ZP; Long, H; Shi, YS; Han, JS; Wan, Y
关键词inflammatory pain chronic pain acupuncture complete Freund&prime s adjuvant naloxone
刊名BRAIN RESEARCH BULLETIN
2004-03-15
DOI10.1016/j.brainresbull.2004.01.006
63期:2页:99-103
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]LONG-LASTING ALLODYNIA ; DIFFERENT FREQUENCIES ; DYNORPHIN-A ; TACTILE ALLODYNIA ; NERVE INJURY ; RECEPTORS ; ANALGESIA ; STIMULATION ; MODULATION ; TOLERANCE
英文摘要

Opioid peptides have been proven effective in reducing the sign of hyperalgesia associated with inflammation. Electroacupuncture (EA) produces antinociception via release of endogenous opioid peptides in normal rats. Moreover, intrathecal injection of dynorphin has antinociceptive effect in rats. The present study was designed to examine whether EA has effect on the thermal and mechanical hyperalgesia in rat model of complete Freund′s adjuvant (CFA)-induced inflammatory pain. The results are the following: (1) single session of 100 Hz EA (0.5-1.0-1.5 mA. 10 min for each intensity) at both Zusanli (ST 36) and Sanyinjiao acupoints (SP 6) significantly increased mechanical withdrawal threshold determined by von Frey filaments but not with thermal withdrawal latency that is determined by hot plate (52 +/- 0.2 degreesC); (2) 100 Hz EA applied twice a week for 4 weeks and showed a significant decrease in the mechanical hyperalgesia at the third and fourth week. with no effect on thermal hyperalgesia; (3) naloxone (20 mg kg(-1)) had the ability to reverse the inhibition of the mechanical hyperalgesia produced by a single session of EA. In conclusion, the present results indicate that a single or repetitive EA could reduce mechanical hyperalgesia. but not thermal hyperalgesia, in CFA-inflammatory pain rats, and the opioid system might be involved in these effects. (C) 2004 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000221534600003
引用统计
被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59945
专题北京大学基础医学院_神经生物学系
作者单位1.Gannan Med Coll, Dept Physiol, Ganzhou 341000, Peoples R China
2.Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Minist Educ, Beijing 100083, Peoples R China
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Huang, C,Hu, ZP,Long, H,et al. Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain[J]. BRAIN RESEARCH BULLETIN,2004,63(2):99-103.
APA Huang, C,Hu, ZP,Long, H,Shi, YS,Han, JS,&Wan, Y.(2004).Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain.BRAIN RESEARCH BULLETIN,63(2),99-103.
MLA Huang, C,et al."Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain".BRAIN RESEARCH BULLETIN 63.2(2004):99-103.
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