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学科主题: 基础医学
题名:
Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain
作者: Huang, C; Hu, ZP; Long, H; Shi, YS; Han, JS; Wan, Y
关键词: inflammatory pain ; chronic pain ; acupuncture ; complete Freund&prime ; s adjuvant ; naloxone
刊名: BRAIN RESEARCH BULLETIN
发表日期: 2004-03-15
DOI: 10.1016/j.brainresbull.2004.01.006
卷: 63, 期:2, 页:99-103
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: LONG-LASTING ALLODYNIA ; DIFFERENT FREQUENCIES ; DYNORPHIN-A ; TACTILE ALLODYNIA ; NERVE INJURY ; RECEPTORS ; ANALGESIA ; STIMULATION ; MODULATION ; TOLERANCE
英文摘要:

Opioid peptides have been proven effective in reducing the sign of hyperalgesia associated with inflammation. Electroacupuncture (EA) produces antinociception via release of endogenous opioid peptides in normal rats. Moreover, intrathecal injection of dynorphin has antinociceptive effect in rats. The present study was designed to examine whether EA has effect on the thermal and mechanical hyperalgesia in rat model of complete Freund′s adjuvant (CFA)-induced inflammatory pain. The results are the following: (1) single session of 100 Hz EA (0.5-1.0-1.5 mA. 10 min for each intensity) at both Zusanli (ST 36) and Sanyinjiao acupoints (SP 6) significantly increased mechanical withdrawal threshold determined by von Frey filaments but not with thermal withdrawal latency that is determined by hot plate (52 +/- 0.2 degreesC); (2) 100 Hz EA applied twice a week for 4 weeks and showed a significant decrease in the mechanical hyperalgesia at the third and fourth week. with no effect on thermal hyperalgesia; (3) naloxone (20 mg kg(-1)) had the ability to reverse the inhibition of the mechanical hyperalgesia produced by a single session of EA. In conclusion, the present results indicate that a single or repetitive EA could reduce mechanical hyperalgesia. but not thermal hyperalgesia, in CFA-inflammatory pain rats, and the opioid system might be involved in these effects. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000221534600003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59945
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Gannan Med Coll, Dept Physiol, Ganzhou 341000, Peoples R China
2.Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Minist Educ, Beijing 100083, Peoples R China

Recommended Citation:
Huang, C,Hu, ZP,Long, H,et al. Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain[J]. BRAIN RESEARCH BULLETIN,2004,63(2):99-103.
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