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学科主题: 临床医学
题名:
Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B
作者: Chen, Ji; Wang, Xiao-Mei2; Wu, Xue-Jie; Wang, Yan; Zhao, Hong; Shen, Bing2; Wang, Gui-Qiang1
关键词: Chronic hepatitis B ; PD-1/PD-L ; Intrahepatic protein expression ; Inflammation
刊名: INFLAMMATION RESEARCH
发表日期: 2011
DOI: 10.1007/s00011-010-0233-1
卷: 60, 期:1, 页:47-53
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: T-CELL-ACTIVATION ; C VIRUS-INFECTION ; DENDRITIC CELL ; PROGRAMMED DEATH-1 ; VIRAL-INFECTION ; PD-1 EXPRESSION ; UP-REGULATION ; B7-H1 ; DYSFUNCTION ; SUPPRESSES
英文摘要:

Background and objective Programed cell death-1 (PD-1) represents a mechanism of T-cell dysfunction in hepatitis B virus (HBV) persistence. In peripheral blood, PD-1 is up-regulated in virus-specific T cells, leading to the impairment of T cells. This study investigated the intrahepatic expression of PD-1 and its ligand (PD-L) in patients with chronic hepatitis B (CHB) virus.

Methods Liver specimens were obtained from CHB (n = 56), acute hepatitis B (AHB, n = 12) patients and age-matched healthy subjects (n = 10). The expression of PD-1/PD-L was determined by immunohistochemistry.

Results In CHB patients, PD-1 was predominantly expressed in lymphocytes infiltrating the portal tract. PD-L1 was detected in lymphocytes, hepatocytes and liver sinusoidal endothelial cells, while PD-L2 was localized in Kupffer cells and dendritic cells. The labeling indexes of PD-1 and PD-L I in lymphocytes infiltrating portal area were significantly higher in CHB patients than in healthy controls and AHB patients. Within the CHB patients, the increases in labeling indexes of PD-1 and PD-L paralleled the degree of inflammation.

Conclusions These results suggest that over-expression of PD-1, PD-L1 and PD-L2 within liver may participate in local immune dysfunction, which could be one of the mechanisms involved in the chronicity of HBV infection and chronic inflammation seen in CHB patients.

语种: 英语
所属项目编号: 30771905 ; 2007CB512800 ; 008ZX10002-008 ; D08050700650803
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China ("973" Program) ; Mega-projects of Science Research ; Beijing Municipal Science &amp ; Technology Commission
WOS记录号: WOS:000286366500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59947
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Dept Infect Dis, Ctr Liver Dis, Hosp 1, Beijing 10034, Peoples R China
2.Beijing Ditan Hosp, Dept Pathol, Beijing 100015, Peoples R China

Recommended Citation:
Chen, Ji,Wang, Xiao-Mei,Wu, Xue-Jie,et al. Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B[J]. INFLAMMATION RESEARCH,2011,60(1):47-53.
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