IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B
Chen, Ji; Wang, Xiao-Mei2; Wu, Xue-Jie; Wang, Yan; Zhao, Hong; Shen, Bing2; Wang, Gui-Qiang1
关键词Chronic Hepatitis b Pd-1/pd-l Intrahepatic Protein Expression Inflammation
刊名INFLAMMATION RESEARCH
2011
DOI10.1007/s00011-010-0233-1
60期:1页:47-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
资助者National Natural Science Foundation of China ; National Basic Research Program of China ("973" Program) ; Mega-projects of Science Research ; Beijing Municipal Science &amp ; Technology Commission ; National Natural Science Foundation of China ; National Basic Research Program of China ("973" Program) ; Mega-projects of Science Research ; Beijing Municipal Science &amp ; Technology Commission
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]T-CELL-ACTIVATION ; C VIRUS-INFECTION ; DENDRITIC CELL ; PROGRAMMED DEATH-1 ; VIRAL-INFECTION ; PD-1 EXPRESSION ; UP-REGULATION ; B7-H1 ; DYSFUNCTION ; SUPPRESSES
英文摘要

Background and objective Programed cell death-1 (PD-1) represents a mechanism of T-cell dysfunction in hepatitis B virus (HBV) persistence. In peripheral blood, PD-1 is up-regulated in virus-specific T cells, leading to the impairment of T cells. This study investigated the intrahepatic expression of PD-1 and its ligand (PD-L) in patients with chronic hepatitis B (CHB) virus.

Methods Liver specimens were obtained from CHB (n = 56), acute hepatitis B (AHB, n = 12) patients and age-matched healthy subjects (n = 10). The expression of PD-1/PD-L was determined by immunohistochemistry.

Results In CHB patients, PD-1 was predominantly expressed in lymphocytes infiltrating the portal tract. PD-L1 was detected in lymphocytes, hepatocytes and liver sinusoidal endothelial cells, while PD-L2 was localized in Kupffer cells and dendritic cells. The labeling indexes of PD-1 and PD-L I in lymphocytes infiltrating portal area were significantly higher in CHB patients than in healthy controls and AHB patients. Within the CHB patients, the increases in labeling indexes of PD-1 and PD-L paralleled the degree of inflammation.

Conclusions These results suggest that over-expression of PD-1, PD-L1 and PD-L2 within liver may participate in local immune dysfunction, which could be one of the mechanisms involved in the chronicity of HBV infection and chronic inflammation seen in CHB patients.

语种英语
所属项目编号30771905 ; 2007CB512800 ; 008ZX10002-008 ; D08050700650803
资助者National Natural Science Foundation of China ; National Basic Research Program of China ("973" Program) ; Mega-projects of Science Research ; Beijing Municipal Science &amp ; Technology Commission ; National Natural Science Foundation of China ; National Basic Research Program of China ("973" Program) ; Mega-projects of Science Research ; Beijing Municipal Science &amp ; Technology Commission
WOS记录号WOS:000286366500007
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59947
Collection北京大学第一临床医学院_感染疾病科
作者单位1.Peking Univ, Dept Infect Dis, Ctr Liver Dis, Hosp 1, Beijing 10034, Peoples R China
2.Beijing Ditan Hosp, Dept Pathol, Beijing 100015, Peoples R China
Recommended Citation
GB/T 7714
Chen, Ji,Wang, Xiao-Mei,Wu, Xue-Jie,et al. Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B[J]. INFLAMMATION RESEARCH,2011,60(1):47-53.
APA Chen, Ji.,Wang, Xiao-Mei.,Wu, Xue-Jie.,Wang, Yan.,Zhao, Hong.,...&Wang, Gui-Qiang.(2011).Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B.INFLAMMATION RESEARCH,60(1),47-53.
MLA Chen, Ji,et al."Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B".INFLAMMATION RESEARCH 60.1(2011):47-53.
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