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Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: Association with dyskinetic movements
Zhang, Xiang Yang1,2; Xiu, Mei Hong2; Chen, Da Chun2; Zhu, Feng Yan2; Wu, Gui Ying1; Haile, Colin N.1; Lu, Lin3; Kosten, Therese A.1; Kosten, Thomas R.1
关键词Tardive dyskinesia Schizophrenia S100B Antipsychotic treatment
刊名JOURNAL OF PSYCHIATRIC RESEARCH
2010-05-01
DOI10.1016/j.jpsychires.2009.10.012
44期:7页:429-433
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
资助者Beijing Municipal Natural Science Foundation ; Stanley Medical Research Institute ; Department of Veterans Affairs ; VISN 16 ; Mental Illness Research, Education and Clinical Center (MIRECC) ; United States National Institute of Health ; Beijing Municipal Natural Science Foundation ; Stanley Medical Research Institute ; Department of Veterans Affairs ; VISN 16 ; Mental Illness Research, Education and Clinical Center (MIRECC) ; United States National Institute of Health
研究领域[WOS]Psychiatry
关键词[WOS]S-100B PROTEIN ; ANTIPSYCHOTICS ; CLOZAPINE ; SYMPTOMS ; BRAIN ; BLOOD
英文摘要

Several studies show that calcium-binding protein S100B is increased in schizophrenia and may be involved in the pathogenesis of tardive dyskinesia (TD). We therefore compared serum S100B levels in normal controls (n = 60), schizophrenic patients with (n = 32) and without TD (n = 50). Assessments included the abnormal involuntary movement scale (AIMS) and the positive and negative syndrome scale (PANSS). Serum S100B levels were measured by enzyme-linked immunosorbent assay (ELISA). The results indicated that patients with TD had higher serum S100B levels than normals and those without TD. Serum S100B levels were positively correlated with AIMS scores in patients with TD. These data suggest that increased S100B levels may be related to neuro-degeneration, associated with TO pathophysiology. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号7072035 ; 03T-459 ; 05T-726 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
资助者Beijing Municipal Natural Science Foundation ; Stanley Medical Research Institute ; Department of Veterans Affairs ; VISN 16 ; Mental Illness Research, Education and Clinical Center (MIRECC) ; United States National Institute of Health ; Beijing Municipal Natural Science Foundation ; Stanley Medical Research Institute ; Department of Veterans Affairs ; VISN 16 ; Mental Illness Research, Education and Clinical Center (MIRECC) ; United States National Institute of Health
WOS记录号WOS:000278240200003
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59948
专题中国药物依赖性研究所
作者单位1.Beijing HuiLongGuan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiang Yang,Xiu, Mei Hong,Chen, Da Chun,et al. Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: Association with dyskinetic movements[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2010,44(7):429-433.
APA Zhang, Xiang Yang.,Xiu, Mei Hong.,Chen, Da Chun.,Zhu, Feng Yan.,Wu, Gui Ying.,...&Kosten, Thomas R..(2010).Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: Association with dyskinetic movements.JOURNAL OF PSYCHIATRIC RESEARCH,44(7),429-433.
MLA Zhang, Xiang Yang,et al."Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: Association with dyskinetic movements".JOURNAL OF PSYCHIATRIC RESEARCH 44.7(2010):429-433.
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