IR@PKUHSC  > 北京大学第二临床医学院  > 麻醉科
学科主题临床医学
Ischemic preconditioning produces more powerful anti-inflammatory and cardioprotective effects than limb remote ischemic postconditioning in rats with myocardial ischemia-reperfusion injury
Zhang Jia-qiang1; Wang Qiang2; Xue Fu-shan3,4; Li Rui-ping3,4; Cheng Yi3,4; Cui Xin-long3,4; Liao Xu2; Meng Fan-min1
关键词myocardial ischemia-reperfusion injury inflammatory response ischemia preconditioning limb remote ischemic postconditioning
刊名CHINESE MEDICAL JOURNAL
2013-10-20
DOI10.3760/cma.j.issn.0366-6999.20130785
126期:20页:3949-3955
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]FACTOR-KAPPA-B ; INFLAMMATORY RESPONSE ; HEART ; INFARCTION ; ACTIVATION ; PROTECTION ; THERAPY ; KINASE ; ALPHA ; MODEL
英文摘要

Background Both ischemic preconditioning (IPC) and limb remote ischemic postconditioning (LRIPOC) have been shown to possess significantly different cardioprotective effects against the myocardial ischemia reperfusion injury (IRI), but no study has compared the anti-inflammatory effects of IPC and LRIPOC during myocardial IRI process. We hypothesized that IPC and LRIPOC would produce different anti-inflammatory effects in an in vivo rat model with myocardial IRI.

Methods Eighty rats were randomly allocated into four equal groups: sham group, IRI group, IPC group and LRIPOC group. In 10 rats randomly selected from each group, serum levels of TNF-alpha, HMGB1, ICAM1, IL-1, IL-6 and IL-10 were assessed, and infarct size was determined. In another 10 rats of each group, myocardial levels of TNF-a, HMGB1, ICAM1, IL-1, IL-6 and IL-10 in both ischemic and non-ischemic regions were measured.

Results The infarct size was significantly lower in IPC and LRIPOC groups than in IRI group. The serum and myocardial levels of pro-inflammatory cytokines including TNF-a, HMGB1, ICAM1, IL-1 and IL-6 during reperfusion were significantly reduced in IPC and LRIPOC groups compared to IRI group. As compared to the IPC group, infarct size, serum level of TNF-a at 60 minutes of reperfusion, serum levels of HMGB1 and ICAM1 at 120 minutes of reperfusion, myocardial levels of TNF-a, ICAM1, IL-1 and IL-6 in the ischemic region, myocardial levels of ICAM1, IL-1 and IL-6 in the non-ischemic region were significantly increased in the LRIPOC group.

Conclusions In the rats with myocardial IRI, IPC produces more powerful inhibitory effects on local myocardial and systemic inflammatory responses than LRIPOC. This may be partly attributed to more potent cardioprotection produced by IPC.

语种英语
所属项目编号30972836
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000326426900031
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59953
Collection北京大学第二临床医学院_麻醉科
作者单位1.Zhengzhou Univ, Dept Anesthesiol, Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing 100044, Peoples R China
3.Chinese Acad Med Sci, Plast Surg Hosp, Dept Anesthesiol, Beijing 100144, Peoples R China
4.Peking Union Med Coll, Beijing 100144, Peoples R China
Recommended Citation
GB/T 7714
Zhang Jia-qiang,Wang Qiang,Xue Fu-shan,et al. Ischemic preconditioning produces more powerful anti-inflammatory and cardioprotective effects than limb remote ischemic postconditioning in rats with myocardial ischemia-reperfusion injury[J]. CHINESE MEDICAL JOURNAL,2013,126(20):3949-3955.
APA Zhang Jia-qiang.,Wang Qiang.,Xue Fu-shan.,Li Rui-ping.,Cheng Yi.,...&Meng Fan-min.(2013).Ischemic preconditioning produces more powerful anti-inflammatory and cardioprotective effects than limb remote ischemic postconditioning in rats with myocardial ischemia-reperfusion injury.CHINESE MEDICAL JOURNAL,126(20),3949-3955.
MLA Zhang Jia-qiang,et al."Ischemic preconditioning produces more powerful anti-inflammatory and cardioprotective effects than limb remote ischemic postconditioning in rats with myocardial ischemia-reperfusion injury".CHINESE MEDICAL JOURNAL 126.20(2013):3949-3955.
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