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Dietary nucleotides extend the life span in Sprague-Dawley rats
Xu, M.1,2; Liang, R.1,2; Guo, Q.1,2; Wang, S.1,2; Zhao, M.1,2; Zhang, Z.1,2; Wang, Junbo1,2; Li, Yong1,2
关键词Dietary nucleotides longevity antioxidant ability Sprague-Dawley rat
刊名JOURNAL OF NUTRITION HEALTH & AGING
2013-03-01
DOI10.1007/s12603-012-0399-z
17期:3页:223-229
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology ; Nutrition & Dietetics
资助者Foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China ; Foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Geriatrics & Gerontology ; Nutrition & Dietetics
关键词[WOS]CALORIC RESTRICTION ; DNA-DAMAGE ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; FREE-RADICALS ; MICE ; CANCER ; LIVER ; AGE ; MALONDIALDEHYDE
英文摘要

To observe the effect of prolonged feeding of dietary nucleotides (NTs), and to clarify the effect of NTs on life extension of Sprague-Dawley rats.

There were 50 Sprague-Dawley rats in each group (male:female ratio=1:1), which were fed diets supplemented with NTs at concentrations of 0%, 0.01%, 0.04%, 0.16% and 0.64% (wt/wt) from the age of 4 weeks until natural death. We investigated the moribundity and mortality, survival time, spontaneous tumor incidence, and serum oxidative status.

NTs have significantly influence body weight of first 3 month old and food consumption of male rats throughout the life span; it did dose-dependently inhibit the age-related decrease in the activities of antioxidant enzymes and the age-related increase in the levels of lipid peroxidation product in both sexes. NTs notably increased the mean life span, and the maximal life span. Compared to the control group, the incidence of death from tumors was decreased in NTs groups of both sexes.

Long-term feeding of NTs could dose-dependently increase life span in Sprague-Dawley rats, especially, the tumor-bearing ones. Moreover, the antioxidative property of NTs may be responsible for the increased life span.

语种英语
所属项目编号2006BAD27B08
资助者Foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China ; Foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000316077100005
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59954
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100871, Peoples R China
2.Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Xu, M.,Liang, R.,Guo, Q.,et al. Dietary nucleotides extend the life span in Sprague-Dawley rats[J]. JOURNAL OF NUTRITION HEALTH & AGING,2013,17(3):223-229.
APA Xu, M..,Liang, R..,Guo, Q..,Wang, S..,Zhao, M..,...&Li, Yong.(2013).Dietary nucleotides extend the life span in Sprague-Dawley rats.JOURNAL OF NUTRITION HEALTH & AGING,17(3),223-229.
MLA Xu, M.,et al."Dietary nucleotides extend the life span in Sprague-Dawley rats".JOURNAL OF NUTRITION HEALTH & AGING 17.3(2013):223-229.
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