北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel
作者: Zhao, Bing-Xiang1; Zhao, Yang1; Huang, Yue1; Luo, Lin-Min1; Song, Ping1; Wang, Xin1; Chen, Su1; Yu, Ke-Fu1; Zhang, Xuan1; Zhang, Qiang1,2
关键词: Tumor pH ; pH-responsive peptide ; Polymeric micelles ; Targeting ; anti-Tumor efficacy
刊名: BIOMATERIALS
发表日期: 2012-03-01
DOI: 10.1016/j.biomaterials.2011.11.078
卷: 33, 期:8, 页:2508-2520
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: BLOCK-COPOLYMER MICELLES ; ACIDIC SOLID TUMORS ; TAT PEPTIDE ; DRUG-DELIVERY ; EXTRACELLULAR PH ; ANTICANCER NANOMEDICINES ; PENETRATING PEPTIDES ; CATIONIC LIPOSOMES ; CONTROLLED-RELEASE ; BLOOD-VESSELS
英文摘要:

The acidic pH in tumor tissues could be used for targeting solid tumors. In the present study, we designed a tumor-specific pH-responsive peptide H7K(R-2)(2), which could respond to the acidic pH in tumor tissues, and prepared H7K(R-2)(2)-modified polymeric micelles containing paclitaxel (PTX-PM-H7K(R-2)(2)) in order to evaluate their potential targeting of tumor cells and tumor endothelial cells and their anti-tumor activity in mice with tumor cells. PTX-FM-H7K(R-2)(2) was prepared by a thin-film hydration method. The in vitro release of PTX from PTX-PM-H7K(R-2)(2) was tested. The in vitro targeting characteristics of H7K(R-2)(2)-modified polymeric micelles on HUVEC (human umbilical vein endothelial cells) and MCF-7 (human breast adenocarcinoma cells) were evaluated. The in vivo targeting activity of H7K(R-2)(2)-modified polymeric micelles and the in vivo anti-tumor activity of PTX-PM-H7K(R-2)(2) were also investigated in MCF-7 tumor-bearing mice. The released PTX from the FTX-PM-H7K(R-2)(2) was not affected by the pH. The targeting activity of the H7K(R-2)(2)-modified polymeric micelles was demonstrated by in vitro flow cytometry and confocal microscopy as well as in vivo biodistribution. PTX-PM-H7K(R-2)(2) produced very marked anti-tumor and anti-angiogenic activity in MCF-7 tumor-bearing mice in vivo. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30873170 ; 2007CB935800 ; 2009CB930300
项目资助者: National natural science foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000300469800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59960
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Bing-Xiang,Zhao, Yang,Huang, Yue,et al. The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel[J]. BIOMATERIALS,2012,33(8):2508-2520.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Bing-Xiang]'s Articles
[Zhao, Yang]'s Articles
[Huang, Yue]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Bing-Xiang]‘s Articles
[Zhao, Yang]‘s Articles
[Huang, Yue]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace