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Design and synthesis of a novel class of furan-based molecules as potential 20S proteasome inhibitors
Fu, Yiqiu; Xu, Bo; Zou, Xiaomin; Ma, Chao; Yang, Xiaoming; Mou, Ke; Fu, Gang; Lu, Yang; Xu, Ping
关键词Proteasome Inhibitor Peptidomimetic Furan Synthesis Antitumor
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2007-02-15
DOI10.1016/j.bmcl.2006.11.020
17期:4页:1102-1106
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]CRYSTAL-STRUCTURE ; UBIQUITIN SYSTEM ; RESOLUTION ; PROTEOLYSIS ; BINDING ; CYCLIN ; YEAST ; ACIDS
英文摘要

A novel class of furan-based compounds as potential 20S proteasome inhibitors have been designed and synthesized, among which nine compounds are peptide derivatives and six molecules are statine peptidomimetics. The C-terminal furanyl moiety was introduced to target molecules as furan-based amino acids. All the compounds were obtained steadily with moderate to high yield. Compound 12 was a selective moderate potent proteasome peptidomimetic inhibitor. It inhibited HepG2 and HL-60 proliferation effectively. (c) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000244636700048
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59961
专题北京大学药学院_药物化学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Dept Med Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Fu, Yiqiu,Xu, Bo,Zou, Xiaomin,et al. Design and synthesis of a novel class of furan-based molecules as potential 20S proteasome inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(4):1102-1106.
APA Fu, Yiqiu.,Xu, Bo.,Zou, Xiaomin.,Ma, Chao.,Yang, Xiaoming.,...&Xu, Ping.(2007).Design and synthesis of a novel class of furan-based molecules as potential 20S proteasome inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(4),1102-1106.
MLA Fu, Yiqiu,et al."Design and synthesis of a novel class of furan-based molecules as potential 20S proteasome inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.4(2007):1102-1106.
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