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学科主题: 基础医学
题名:
Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute
作者: Li, Suping1,2; Hu, Tao1; Chen, Yali1; Wang, Xianwei3; Liu, Tao1,2; Ma, Guanghui1; Su, Zhiguo1
关键词: carboxylmethylation ; colloid osmotic pressure ; konjac glucomannan ; plasma substitute
刊名: GLYCOBIOLOGY
发表日期: 2010-08-01
DOI: 10.1093/glycob/cwq050
卷: 20, 期:8, 页:950-958
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: HYDROXYETHYL STARCH ; FLUID RESUSCITATION ; MOLECULAR-WEIGHT ; SEPTIC SHOCK ; BLOOD-COAGULATION ; HEMORRHAGIC-SHOCK ; SEVERE SEPSIS ; SALINE ; REPLACEMENT ; GELATIN
英文摘要:

Carboxylmethylated konjac glucomannan (CKGM) is a carboxylmethylated polymer of mannose and glucose that is derived from the plant Amorphophallus konjac cultivated in East Asia. The CKGM solution had a high volume-expanding efficacy and was evaluated as a plasma substitute in the present study. Ameliorative hemorrhagic shock rabbits were used as the model animals. The in vivo hemodynamic and hemorheologic properties, including blood pressure, blood viscosity, hematocrit, erythrocyte deformation index and erythrocyte aggregation index, were measured in animals treated in the CKGM solution. The in vitro colloid osmotic pressure (COP) of the CKGM solution was measured to estimate its plasma-expanding efficacy. These parameters of the CKGM-treated group were compared with groups exposed to four other treatments: human serum albumin (HSA), hydroxyethyl starch (HES), polygeline and normal saline. The CKGM solution showed an exceptionally higher COP than other therapy solutions. For example, the COP of 1% (weight in volume [w/v]) CKGM solution is comparable to those of 6% (w/v) HES solution and 5% (w/v) HSA solution. Accordingly, the CKGM solution can be transfused in a much lower dosage while maintaining its plasma-expanding efficacy. The CKGM-treated group showed an improved intravascular persistence and good hemodynamic and hemorheological properties. Biopsy analysis suggested no organ dysfunction in the group treated in CKGM solution. Moreover, the high plasma-expanding efficacy and inexpensive availability of the CKGM solution may facilitate its clinical application as a potential plasma substitute.

语种: 英语
所属项目编号: 20906095 ; 20636010 ; 20820102036 ; 2007CB714305 ; 2007AA021604
项目资助者: Natural Science Foundation of China ; National Basic Research Program of China ; National 863 High-Tech Project
WOS记录号: WOS:000279469900002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59968
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Sch Basic Med Sci,Hemorheol ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Suping,Hu, Tao,Chen, Yali,et al. Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute[J]. GLYCOBIOLOGY,2010,20(8):950-958.
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