IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute
Li, Suping1,2; Hu, Tao1; Chen, Yali1; Wang, Xianwei3; Liu, Tao1,2; Ma, Guanghui1; Su, Zhiguo1
关键词carboxylmethylation colloid osmotic pressure konjac glucomannan plasma substitute
刊名GLYCOBIOLOGY
2010-08-01
DOI10.1093/glycob/cwq050
20期:8页:950-958
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]HYDROXYETHYL STARCH ; FLUID RESUSCITATION ; MOLECULAR-WEIGHT ; SEPTIC SHOCK ; BLOOD-COAGULATION ; HEMORRHAGIC-SHOCK ; SEVERE SEPSIS ; SALINE ; REPLACEMENT ; GELATIN
英文摘要

Carboxylmethylated konjac glucomannan (CKGM) is a carboxylmethylated polymer of mannose and glucose that is derived from the plant Amorphophallus konjac cultivated in East Asia. The CKGM solution had a high volume-expanding efficacy and was evaluated as a plasma substitute in the present study. Ameliorative hemorrhagic shock rabbits were used as the model animals. The in vivo hemodynamic and hemorheologic properties, including blood pressure, blood viscosity, hematocrit, erythrocyte deformation index and erythrocyte aggregation index, were measured in animals treated in the CKGM solution. The in vitro colloid osmotic pressure (COP) of the CKGM solution was measured to estimate its plasma-expanding efficacy. These parameters of the CKGM-treated group were compared with groups exposed to four other treatments: human serum albumin (HSA), hydroxyethyl starch (HES), polygeline and normal saline. The CKGM solution showed an exceptionally higher COP than other therapy solutions. For example, the COP of 1% (weight in volume [w/v]) CKGM solution is comparable to those of 6% (w/v) HES solution and 5% (w/v) HSA solution. Accordingly, the CKGM solution can be transfused in a much lower dosage while maintaining its plasma-expanding efficacy. The CKGM-treated group showed an improved intravascular persistence and good hemodynamic and hemorheological properties. Biopsy analysis suggested no organ dysfunction in the group treated in CKGM solution. Moreover, the high plasma-expanding efficacy and inexpensive availability of the CKGM solution may facilitate its clinical application as a potential plasma substitute.

语种英语
WOS记录号WOS:000279469900002
项目编号20906095 ; 20636010 ; 20820102036 ; 2007CB714305 ; 2007AA021604
资助机构Natural Science Foundation of China ; National Basic Research Program of China ; National 863 High-Tech Project
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59968
专题北京大学基础医学院_生物物理学系
作者单位1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Sch Basic Med Sci,Hemorheol ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Suping,Hu, Tao,Chen, Yali,et al. Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute[J]. GLYCOBIOLOGY,2010,20(8):950-958.
APA Li, Suping.,Hu, Tao.,Chen, Yali.,Wang, Xianwei.,Liu, Tao.,...&Su, Zhiguo.(2010).Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute.GLYCOBIOLOGY,20(8),950-958.
MLA Li, Suping,et al."Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute".GLYCOBIOLOGY 20.8(2010):950-958.
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