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学科主题: 临床医学
题名:
Antifibrotic effect of the Chinese herbs, Astragalus mongholicus and Angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis
作者: Wang, H; Li, JZ; Yu, L; Zhao, YN; Ding, W
关键词: Astragalus ; Angelica ; glomerulosclerosis ; tubulointerstitial fibrosis ; renin-angiotensin system ; transforming ; growth factor-beta ; osteopontin ; macrophage ; alpha-smooth muscle actin
刊名: LIFE SCIENCES
发表日期: 2004-02-13
DOI: 10.1016/S0024-3205(03)01060-9
卷: 74, 期:13, 页:1645-1658
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: GROWTH-FACTOR-BETA ; ANGIOTENSIN-CONVERTING ENZYME ; RENAL-DISEASE ; OSTEOPONTIN EXPRESSION ; MESANGIAL CELLS ; II ANTAGONISTS ; TGF-BETA ; FIBROSIS ; KIDNEY ; GLOMERULONEPHRITIS
英文摘要:

Nephrotic syndrome has long been treated in China with two herbs, Astragalus mongholicus and Angelica sinensis, which may have antifibrotic effects. Methods: Rats with chronic puromycin-induced nephrosis were treated with Astragalus and Angelica 3 mL/d (n = 7) or enalapril 10 mg/kg/d (n = 7). Normal control rats (n = 7) received saline rather than puromycin, and an untreated control group (n = 7) received puromycin but no treatment. After 12 weeks, stained sections of the glomerulus and tubulointerstitium were evaluated for injury. Immunohistochemistry staining measured extracellular matrix components, transforming growth factor-beta1 (TGFbeta1), osteopontin, ED-1-positive cells, and alpha-actin. TGF (a) over cap1 mRNA was assessed by in situ hybridization. Renin, ACE activity, angiotensin, and aldosterone were measured by radioimmunoassay or colorimetry. In the untreated rats, chronic renal injury progressed to marked fibrosis at 12 weeks. Astragalus and Angelica significantly reduced deterioration of renal function and histologic damage. Expressions of type III and IV collagen, fibronectin, and laminin also decreased significantly. This anti-fibrotic effect was similar to that of enalapril. The herbs had no effect on the renin-angiotensin system but did reduce the number of ED-1-positive, and alpha-actin positive cells and expression of osteopontin compared to untreated controls. The combination of Astragalus and Angelica retarded the progression of renal fibrosis and deterioration of renal function with comparable effects of enalapril These effects were not caused by blocking the intrarenal renin-angiotensin system, but associated with suppression of the overexpression of TGFbeta(1) and osteopontin, reduction of infiltrating macrophages, and less activation of renal intrinsic cells. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000188539700007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59970
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Div Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, H,Li, JZ,Yu, L,et al. Antifibrotic effect of the Chinese herbs, Astragalus mongholicus and Angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis[J]. LIFE SCIENCES,2004,74(13):1645-1658.
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