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学科主题: 临床医学
题名:
Salicylate blocks L-type calcium channels in rat inferior colliculus neurons
作者: Liu, YX; Li, XP; Ma, CS; Liu, JX; Lu, H
关键词: calcium currents ; inferior colliculus ; patch clamp ; salicylate ; tinnitus
刊名: HEARING RESEARCH
发表日期: 2005-07-01
DOI: 10.1016/j.heares.2005.03.028
卷: 205, 期:1-2, 页:271-276
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Audiology & Speech-Language Pathology ; Neurosciences ; Otorhinolaryngology
研究领域[WOS]: Audiology & Speech-Language Pathology ; Neurosciences & Neurology ; Otorhinolaryngology
关键词[WOS]: HIPPOCAMPAL-NEURONS ; CA2+ CHANNELS
英文摘要:

To investigate the effects of the tinnitus inducer sodium salicylate on L-type voltage-gated calcium channels, we studied freshly (-)dissociated inferior colliculus neurons of rats by the whole-cell voltage clamp method. Salicylate′s blocking of L-type calcium Channels was concentration dependent, and the IC50 value of salicylate was estimated to be 1.99 mM. An amount of 1 mM salicylate significantly shifted the steady-state inactivation curve of L-type calcium channels about 9mV in the hyperpolarizing direction and significantly delayed calcium channel recovery. Our results suggest that salicylate′s blocking of L-type calcium channels may contribute to salicylate-induced tinnitus by decreasing GABA release in the inferior colliculus. (c) 2005 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000230239400027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59975
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Peking Univ, Third Hosp, Dept Otorhinolaryngol, Beijing 100083, Haidian Dist, Peoples R China
2.Hebei Med Univ, Dept Neurobiol, Shijiazhuang 050017, Peoples R China
3.Hebei Med Univ, Hosp 2, Dept Otorhinolaryngol, Shijiazhuang 050000, Peoples R China

Recommended Citation:
Liu, YX,Li, XP,Ma, CS,et al. Salicylate blocks L-type calcium channels in rat inferior colliculus neurons[J]. HEARING RESEARCH,2005,205(1-2):271-276.
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