IR@PKUHSC  > 北京大学药学院
学科主题药学
Studies of the effects of anti-tumor compounds on the assembly and melting denaturation of tubulin in vitro
Zhou, XL; Wang, BH; Li, ZF; Zeng, HH
关键词Tubulin Taxol Carboplatin Zyz F43 Turbidity Dsc (Differential Scanning Calorimetry)
刊名ACTA PHYSICO-CHIMICA SINICA
2002-11-01
DOI10.3866/PKU.WHXB20021110
18期:11页:1009-1013
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]DIFFERENTIAL SCANNING CALORIMETRY ; ACTIN POLYMERIZATION ; BRAIN TUBULIN ; CISPLATIN ; COMPLEXES ; BINDING ; INVITRO
英文摘要

The effects of four kinds of anti-tumor compounds, taxol, carboplatin, ZYZ (the extractive from gleditsia), F43 (the extractive from squamocin), on the assembly and melting denaturation of tubulin in vitro were studied by turbidity and differential scanning calorimetry. The experimental results show that taxol and ZYZ enhance the assembly of tubulin, while carboplatin and F43 have no effect on the assembly of tubulin when the concentrations of all four kinds of compounds are 15 mumol (.) L-1. At the same time, taxol and ZYZ can make the melting points of tubuin rise, while the melting points of tubuin don′t change in the presence of carboplatin and F43. The different interaction mechanisms of the compounds and tubulin have been discussed according to the above experimental results.

语种英语
WOS记录号WOS:000179364700010
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59976
专题北京大学药学院
作者单位1.Peking Univ, Inst Chem Phys, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhou, XL,Wang, BH,Li, ZF,et al. Studies of the effects of anti-tumor compounds on the assembly and melting denaturation of tubulin in vitro[J]. ACTA PHYSICO-CHIMICA SINICA,2002,18(11):1009-1013.
APA Zhou, XL,Wang, BH,Li, ZF,&Zeng, HH.(2002).Studies of the effects of anti-tumor compounds on the assembly and melting denaturation of tubulin in vitro.ACTA PHYSICO-CHIMICA SINICA,18(11),1009-1013.
MLA Zhou, XL,et al."Studies of the effects of anti-tumor compounds on the assembly and melting denaturation of tubulin in vitro".ACTA PHYSICO-CHIMICA SINICA 18.11(2002):1009-1013.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhou, XL]的文章
[Wang, BH]的文章
[Li, ZF]的文章
百度学术
百度学术中相似的文章
[Zhou, XL]的文章
[Wang, BH]的文章
[Li, ZF]的文章
必应学术
必应学术中相似的文章
[Zhou, XL]的文章
[Wang, BH]的文章
[Li, ZF]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。