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学科主题: 药学
题名:
Studies of the effects of anti-tumor compounds on the assembly and melting denaturation of tubulin in vitro
作者: Zhou, XL; Wang, BH; Li, ZF; Zeng, HH
关键词: tubulin ; taxol ; carboplatin ; ZYZ ; F43 ; turbidity ; DSC (differential scanning calorimetry)
刊名: ACTA PHYSICO-CHIMICA SINICA
发表日期: 2002-11-01
DOI: 10.3866/PKU.WHXB20021110
卷: 18, 期:11, 页:1009-1013
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
关键词[WOS]: DIFFERENTIAL SCANNING CALORIMETRY ; ACTIN POLYMERIZATION ; BRAIN TUBULIN ; CISPLATIN ; COMPLEXES ; BINDING ; INVITRO
英文摘要:

The effects of four kinds of anti-tumor compounds, taxol, carboplatin, ZYZ (the extractive from gleditsia), F43 (the extractive from squamocin), on the assembly and melting denaturation of tubulin in vitro were studied by turbidity and differential scanning calorimetry. The experimental results show that taxol and ZYZ enhance the assembly of tubulin, while carboplatin and F43 have no effect on the assembly of tubulin when the concentrations of all four kinds of compounds are 15 mumol (.) L-1. At the same time, taxol and ZYZ can make the melting points of tubuin rise, while the melting points of tubuin don′t change in the presence of carboplatin and F43. The different interaction mechanisms of the compounds and tubulin have been discussed according to the above experimental results.

语种: 英语
WOS记录号: WOS:000179364700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59976
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Inst Chem Phys, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, XL,Wang, BH,Li, ZF,et al. Studies of the effects of anti-tumor compounds on the assembly and melting denaturation of tubulin in vitro[J]. ACTA PHYSICO-CHIMICA SINICA,2002,18(11):1009-1013.
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