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学科主题临床医学
Bispectral index monitoring prevent awareness during total intravenous anesthesia: a prospective, randomized, double-blinded, multi-center controlled trial
Zhang Chen1; Xu Liang2; Ma Ya-qun3; Sun Yan-xia4; Li Yan-hong5; Zhang Liang6; Feng Chun-sheng7; Luo Bing8; Zhao Zhen-long9; Guo Jian-rong10; Jin Yao-jun11; Wu Gang12; Yuan Wei13; Yuan Zhi-guo14; Yue Yun1
关键词awareness complications general anesthesia monitoring bispectral index
刊名CHINESE MEDICAL JOURNAL
2011-11-20
DOI10.3760/cma.j.issn.0366-6999.2011.22.012
124期:22页:3664-3669
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]GENERAL-ANESTHESIA ; RECALL ; DEPTH ; RISK ; BIS
英文摘要

Background Awareness is a serious complication of general anesthesia. In China, the incidence of intraoperative awareness was 1% in patients undergoing total intravenous anesthesia (TIVA). In this study, we compared the incidence of awareness between Bispectral index (BIS)-guided and routine TIVA protocol and evaluated the effect of BIS on preventing awareness.

Methods A prospective, randomized, double-blinded, multicenter controlled trial was performed. Patients (>= 18 years of age) undergoing TIVA were randomly divided into BIS-guided group (Group A, BIS was monitored and recommended to maintain between 40-60) and control group (Group B, BIS was monitored but the screen was covered). The intraoperative BIS values were downloaded and the BIS trends of confirmed awareness cases were analyzed to determine whether light anesthesia existed.

Results Of the total 5228 patients, 2919 patients were assigned to Group A and 2309 to Group B. Four cases of confirmed awareness (0.14%) were reported in the BIS-guided group and 15 (0.65%) in the control group (P=0.002, OR=0.21, 95% confidence intervals: 0.07-0.63). The incidence of possible awareness (0.14% vs. 0.26%, P=0.485) and dreaming (3.1% vs. 3.1%, P=0.986) was comparable between BIS-guided group and the control group. Among the 19 confirmed awareness cases, intraoperative BIS trends of six cases were downloaded and identified. Five of them showed signs of light anesthesia as BIS >60 and lasted 19-106 minutes, whereas one case had a stable BIS trend and the values were within 60 during the operation. Another five awareness cases were reviewed for anesthesia procedures, of which improper light anesthesia were confirmed.

Conclusions BIS-guided TIVA (BIS was recommended to maintain between 40-60) decreased the risk of awareness compared with routine TIVA. The main reason for awareness was light anesthesia. Chin Med J 2011;124(22):3664-3669

语种英语
WOS记录号WOS:000297658300012
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59978
专题北京大学第三临床医学院_麻醉科
作者单位1.Capital Med Univ, Beijing Chaoyang Hosp, Dept Anesthesiol, Beijing 100020, Peoples R China
2.Subei Peoples Hosp Jiangsu Prov, Dept Anesthesiol, Yangzhou 225001, Jiangsu, Peoples R China
3.Mil Gen Hosp Beijing Peoples Liberat Army, Dept Anesthesiol, Beijing 100700, Peoples R China
4.Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesiol, Beijing 100730, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Anesthesiol, Beijing 100053, Peoples R China
6.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100193, Peoples R China
7.Jilin Univ, Hosp 1, Dept Anesthesiol, Changchun 130021, Jilin, Peoples R China
8.Guangzhou First Municipal Peoples Hosp, Dept Anesthesiol, Guangzhou 510180, Guangdong, Peoples R China
9.So Med Univ, Nanfang Hosp, Dept Anesthesiol, Guangzhou 510515, Guangdong, Peoples R China
10.Ningbo Univ, Coll Med, Lihuili Hosp, Dept Anesthesiol, Ningbo 315041, Zhejiang, Peoples R China
11.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Anesthesiol, Shanghai 200092, Peoples R China
12.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 2, Dept Anesthesiol, Xian 710004, Shaanxi, Peoples R China
13.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Anesthesiol, Xian 710004, Shaanxi, Peoples R China
14.China Med Univ, Hosp 1, Dept Anesthesiol, Shenyang 110001, Liaoning, Peoples R China
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Zhang Chen,Xu Liang,Ma Ya-qun,et al. Bispectral index monitoring prevent awareness during total intravenous anesthesia: a prospective, randomized, double-blinded, multi-center controlled trial[J]. CHINESE MEDICAL JOURNAL,2011,124(22):3664-3669.
APA Zhang Chen.,Xu Liang.,Ma Ya-qun.,Sun Yan-xia.,Li Yan-hong.,...&Yue Yun.(2011).Bispectral index monitoring prevent awareness during total intravenous anesthesia: a prospective, randomized, double-blinded, multi-center controlled trial.CHINESE MEDICAL JOURNAL,124(22),3664-3669.
MLA Zhang Chen,et al."Bispectral index monitoring prevent awareness during total intravenous anesthesia: a prospective, randomized, double-blinded, multi-center controlled trial".CHINESE MEDICAL JOURNAL 124.22(2011):3664-3669.
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