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Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid
Yang, JH; Jiang, W; Pan, CS; Qi, YF; Wu, QZ; Pang, YZ; Tang, CS
关键词lysophosphatidic acid adrenomedullin proliferation adventitia
刊名REGULATORY PEPTIDES
2004-09-15
DOI10.1016/j.regpep.2004.04.005
121期:1-3页:49-56
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Physiology
研究领域[WOS]Endocrinology & Metabolism ; Physiology
关键词[WOS]ANGIOTENSIN-II ; RECEPTOR ; PEPTIDE ; ENDOTHELIN-1 ; PROADRENOMEDULLIN ; DIFFERENTIATION ; FIBROBLASTS ; EXPRESSION ; RESPONSES ; MEDIATOR
英文摘要

Lysophosphatidic acid (LPA) is a bioactive phospholipid having growth factor-like activity on fibroblasts and is involved in cardiovascular diseases such as hypertension and heart failure by inducing vascular remodeling, characterized by fibroblast proliferation and migration in adventitia. Among various bioactive factors that LPA works with, adrenomedullin (ADM) is a multiple functional peptide with an important cytoprotective effect against cardiovascular damage. We studied rat aortic adventitia to explore the possible paracrine/autocrine interaction between endogenous ADM and LPA. LPA stimulation of the adventitia to secrete ADM and express its mRNA was concentration dependent. ADM inhibited LPA-induced proliferation in adventitial cells and attenuated the activity of mitogen-activated protein kinase (MAPK) stimulated by LPA. In contrast, treatment with specific antagonists of the ADM receptor potentiated the LPA-induced proliferation in adventitial cells. We concluded that LPA stimulates the adventitia to produce and secrete ADM, which in turn regulates the vascular biological effects of LPA. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000222925200007
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59979
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
3.Minist Hlth Cardiovasc Mol Biol & Regulatory Pept, Reference Lab, Beijing 100083, Peoples R China
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GB/T 7714
Yang, JH,Jiang, W,Pan, CS,et al. Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid[J]. REGULATORY PEPTIDES,2004,121(1-3):49-56.
APA Yang, JH.,Jiang, W.,Pan, CS.,Qi, YF.,Wu, QZ.,...&Tang, CS.(2004).Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid.REGULATORY PEPTIDES,121(1-3),49-56.
MLA Yang, JH,et al."Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid".REGULATORY PEPTIDES 121.1-3(2004):49-56.
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