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学科主题: 临床医学
题名:
Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid
作者: Yang, JH; Jiang, W; Pan, CS; Qi, YF; Wu, QZ; Pang, YZ; Tang, CS
关键词: lysophosphatidic acid ; adrenomedullin ; proliferation ; adventitia
刊名: REGULATORY PEPTIDES
发表日期: 2004-09-15
DOI: 10.1016/j.regpep.2004.04.005
卷: 121, 期:1-3, 页:49-56
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Physiology
研究领域[WOS]: Endocrinology & Metabolism ; Physiology
关键词[WOS]: ANGIOTENSIN-II ; RECEPTOR ; PEPTIDE ; ENDOTHELIN-1 ; PROADRENOMEDULLIN ; DIFFERENTIATION ; FIBROBLASTS ; EXPRESSION ; RESPONSES ; MEDIATOR
英文摘要:

Lysophosphatidic acid (LPA) is a bioactive phospholipid having growth factor-like activity on fibroblasts and is involved in cardiovascular diseases such as hypertension and heart failure by inducing vascular remodeling, characterized by fibroblast proliferation and migration in adventitia. Among various bioactive factors that LPA works with, adrenomedullin (ADM) is a multiple functional peptide with an important cytoprotective effect against cardiovascular damage. We studied rat aortic adventitia to explore the possible paracrine/autocrine interaction between endogenous ADM and LPA. LPA stimulation of the adventitia to secrete ADM and express its mRNA was concentration dependent. ADM inhibited LPA-induced proliferation in adventitial cells and attenuated the activity of mitogen-activated protein kinase (MAPK) stimulated by LPA. In contrast, treatment with specific antagonists of the ADM receptor potentiated the LPA-induced proliferation in adventitial cells. We concluded that LPA stimulates the adventitia to produce and secrete ADM, which in turn regulates the vascular biological effects of LPA. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000222925200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59979
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
3.Minist Hlth Cardiovasc Mol Biol & Regulatory Pept, Reference Lab, Beijing 100083, Peoples R China

Recommended Citation:
Yang, JH,Jiang, W,Pan, CS,et al. Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid[J]. REGULATORY PEPTIDES,2004,121(1-3):49-56.
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