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学科主题: 临床医学
题名:
Urinary Levels of High Mobility Group Box-1 Are Associated with Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
作者: Ma, Tian-Tian; Wang, Huan; Wang, Chen; Chang, Dong-Yuan; Zhao, Ming-Hui; Chen, Min
刊名: PLOS ONE
发表日期: 2015-04-17
DOI: 10.1371/journal.pone.0123586
卷: 10, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ANCA-ASSOCIATED VASCULITIS ; RENAL MANIFESTATIONS ; CHROMATIN PROTEIN ; HMGB1 ; INFLAMMATION ; GLOMERULONEPHRITIS ; CLASSIFICATION ; RECEPTOR ; MARKER
英文摘要:

Background

High mobility group box-1 (HMGB1), a kind of pro-inflammatory mediator, is associated with inflammatory conditions and tissue damage. Our previous study demonstrated that the circulating levels of HMGB1 correlated with disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In the current study, we aimed to measure urinary levels of HMGB1 in AAV patients, correlated them to clinical activity index and analysed the immunohistochemical HMGB1 staining in kidney specimens.

Methods

50 patients with AAV in active stage and 56 patients with AAV in remission were recruited. The urinary levels of HMGB1 were determined by enzyme-linked immunosorbent assay. Moreover, renal biopsy specimens from 27 patients with active AAV were randomly collected to evaluate the deposition of HMGB1.

Results

Urinary HMGB1 levels in AAV patients in active stage were significantly higher than those in AAV patients in remission and healthy controls (1.46 [0.56-3.43] versus 0.38 [0.10-1.35] mg/mu molCr, P= 0.001; 1.46 [0.56-3.43] versus 0.48 [0.40-0.60] mg/mu molCr, P= 0.000, respectively). Further analysis found that urinary levels of HMGB1 correlated with erythrocyte sedimentation rate (r=0.354, p=0.012), C-reactive protein (r=0.289, p=0.042), and Birmingham Vasculitis Activity Score (r=0.350, p=0.013). Renal tissue of active AAV patients showed HMGB1 was mainly expressed in the cytoplasm and the extracellular space. The percentage of HMGB1-negative nuclei in renal tissue of patients with active AAV was significantly higher than that in normal controls (60.6 +/- 20.2 % versus 2.7 +/- 0.6 %, p<0.01).

Conclusion

Urinary levels of HMGB1 may be associated with the disease activity in AAV patients.

语种: 英语
所属项目编号: 2012CB517702 ; 20120001110018 ; 81425008 ; 81321064 ; 81300599 ; 2011BAI10B04
项目资助者: Chinese 973 project ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Fund ; "National Key Technology Research and Development (R&amp ; D) Program" of the Ministry of Science and Technology of China
WOS记录号: WOS:000353017000076
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59986
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Ma, Tian-Tian,Wang, Huan,Wang, Chen,et al. Urinary Levels of High Mobility Group Box-1 Are Associated with Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis[J]. PLOS ONE,2015,10(4).
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