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学科主题临床医学
Urinary Levels of High Mobility Group Box-1 Are Associated with Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
Ma, Tian-Tian; Wang, Huan; Wang, Chen; Chang, Dong-Yuan; Zhao, Ming-Hui; Chen, Min
刊名PLOS ONE
2015-04-17
DOI10.1371/journal.pone.0123586
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ANCA-ASSOCIATED VASCULITIS ; RENAL MANIFESTATIONS ; CHROMATIN PROTEIN ; HMGB1 ; INFLAMMATION ; GLOMERULONEPHRITIS ; CLASSIFICATION ; RECEPTOR ; MARKER
英文摘要

Background

High mobility group box-1 (HMGB1), a kind of pro-inflammatory mediator, is associated with inflammatory conditions and tissue damage. Our previous study demonstrated that the circulating levels of HMGB1 correlated with disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In the current study, we aimed to measure urinary levels of HMGB1 in AAV patients, correlated them to clinical activity index and analysed the immunohistochemical HMGB1 staining in kidney specimens.

Methods

50 patients with AAV in active stage and 56 patients with AAV in remission were recruited. The urinary levels of HMGB1 were determined by enzyme-linked immunosorbent assay. Moreover, renal biopsy specimens from 27 patients with active AAV were randomly collected to evaluate the deposition of HMGB1.

Results

Urinary HMGB1 levels in AAV patients in active stage were significantly higher than those in AAV patients in remission and healthy controls (1.46 [0.56-3.43] versus 0.38 [0.10-1.35] mg/mu molCr, P= 0.001; 1.46 [0.56-3.43] versus 0.48 [0.40-0.60] mg/mu molCr, P= 0.000, respectively). Further analysis found that urinary levels of HMGB1 correlated with erythrocyte sedimentation rate (r=0.354, p=0.012), C-reactive protein (r=0.289, p=0.042), and Birmingham Vasculitis Activity Score (r=0.350, p=0.013). Renal tissue of active AAV patients showed HMGB1 was mainly expressed in the cytoplasm and the extracellular space. The percentage of HMGB1-negative nuclei in renal tissue of patients with active AAV was significantly higher than that in normal controls (60.6 +/- 20.2 % versus 2.7 +/- 0.6 %, p<0.01).

Conclusion

Urinary levels of HMGB1 may be associated with the disease activity in AAV patients.

语种英语
WOS记录号WOS:000353017000076
项目编号2012CB517702 ; 20120001110018 ; 81425008 ; 81321064 ; 81300599 ; 2011BAI10B04
资助机构Chinese 973 project ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Fund ; "National Key Technology Research and Development (R&amp ; D) Program" of the Ministry of Science and Technology of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59986
专题北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ma, Tian-Tian,Wang, Huan,Wang, Chen,et al. Urinary Levels of High Mobility Group Box-1 Are Associated with Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis[J]. PLOS ONE,2015,10(4).
APA Ma, Tian-Tian,Wang, Huan,Wang, Chen,Chang, Dong-Yuan,Zhao, Ming-Hui,&Chen, Min.(2015).Urinary Levels of High Mobility Group Box-1 Are Associated with Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis.PLOS ONE,10(4).
MLA Ma, Tian-Tian,et al."Urinary Levels of High Mobility Group Box-1 Are Associated with Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis".PLOS ONE 10.4(2015).
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