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Dual-Targeted Molecular Probes for Cancer Imaging
Liu, Zhaofei1,2; Wang, Fan1,2
关键词Tumor receptor molecular imaging dual-targeted peptide heterodimer
刊名CURRENT PHARMACEUTICAL BIOTECHNOLOGY
2010-09-01
11期:6页:610-619
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]POSITRON-EMITTING RADIOTRACERS ; RGD-BOMBESIN HETERODIMER ; GROWTH-FACTOR RECEPTOR ; PEPTIDE-BASED PROBES ; TUMOR ANGIOGENESIS ; PROSTATE-CANCER ; IN-VIVO ; NEUROENDOCRINE TUMORS ; BISPECIFIC ANTIBODIES ; MULTIMERIC LIGANDS
英文摘要

Molecular imaging provides a powerful tool for early disease detection, characterization, and real-time monitoring of therapeutic responses. Central to molecular imaging is the development of imaging probes. Receptors that are over-expressed in tumors have been potential targets for cancer imaging using targeted molecular probes. Since many cancer types simultaneously overexpress several receptors, the design of dual receptor-targeted molecular imaging probes has recently been proposed. Peptide heterodimers, and microbubble-based dual-targeted probes have shown especially good performance for in vivo cancer imaging. The success of these molecular probes demonstrates that the dual-targeting strategy is generally a good approach for developing molecular probes. In this review, we will introduce the current state of development of dual-targeted molecular imaging probes and summarize the various dual-targeted molecular probes for in vivo cancer imaging.

语种英语
WOS记录号WOS:000281435100008
项目编号30870728 ; 20820102035 ; 30930030 ; 30900373 ; 2007A-A02Z467 ; 2009ZX09103-733 ; 2009ZX09301-010 ; 2009ZX09103-746
资助机构NSFC ; "863" project ; Ministry of Science and Technology of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59992
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China
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Liu, Zhaofei,Wang, Fan. Dual-Targeted Molecular Probes for Cancer Imaging[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2010,11(6):610-619.
APA Liu, Zhaofei,&Wang, Fan.(2010).Dual-Targeted Molecular Probes for Cancer Imaging.CURRENT PHARMACEUTICAL BIOTECHNOLOGY,11(6),610-619.
MLA Liu, Zhaofei,et al."Dual-Targeted Molecular Probes for Cancer Imaging".CURRENT PHARMACEUTICAL BIOTECHNOLOGY 11.6(2010):610-619.
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