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学科主题: 公共卫生
题名:
Dual-Targeted Molecular Probes for Cancer Imaging
作者: Liu, Zhaofei1,2; Wang, Fan1,2
关键词: Tumor ; receptor ; molecular imaging ; dual-targeted ; peptide heterodimer
刊名: CURRENT PHARMACEUTICAL BIOTECHNOLOGY
发表日期: 2010-09-01
卷: 11, 期:6, 页:610-619
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: POSITRON-EMITTING RADIOTRACERS ; RGD-BOMBESIN HETERODIMER ; GROWTH-FACTOR RECEPTOR ; PEPTIDE-BASED PROBES ; TUMOR ANGIOGENESIS ; PROSTATE-CANCER ; IN-VIVO ; NEUROENDOCRINE TUMORS ; BISPECIFIC ANTIBODIES ; MULTIMERIC LIGANDS
英文摘要:

Molecular imaging provides a powerful tool for early disease detection, characterization, and real-time monitoring of therapeutic responses. Central to molecular imaging is the development of imaging probes. Receptors that are over-expressed in tumors have been potential targets for cancer imaging using targeted molecular probes. Since many cancer types simultaneously overexpress several receptors, the design of dual receptor-targeted molecular imaging probes has recently been proposed. Peptide heterodimers, and microbubble-based dual-targeted probes have shown especially good performance for in vivo cancer imaging. The success of these molecular probes demonstrates that the dual-targeting strategy is generally a good approach for developing molecular probes. In this review, we will introduce the current state of development of dual-targeted molecular imaging probes and summarize the various dual-targeted molecular probes for in vivo cancer imaging.

语种: 英语
所属项目编号: 30870728 ; 20820102035 ; 30930030 ; 30900373 ; 2007A-A02Z467 ; 2009ZX09103-733 ; 2009ZX09301-010 ; 2009ZX09103-746
项目资助者: NSFC ; "863" project ; Ministry of Science and Technology of China
WOS记录号: WOS:000281435100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59992
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Zhaofei,Wang, Fan. Dual-Targeted Molecular Probes for Cancer Imaging[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2010,11(6):610-619.
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