学科主题基础医学
Mid-trimester fetal blood-derived adherent cells share characteristics similar to mesenchymal stem cells but full-term umbilical cord blood does not
Yu, MJ; Xiao, ZF; Shen, L; Li, LS
关键词fetal blood umbilical cord blood mesenchymal stem cells phenotype differentiation
刊名BRITISH JOURNAL OF HAEMATOLOGY
2004-03-01
DOI10.1111/j.1365-2141.2004.04826.x
124期:5页:666-675
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]MARROW STROMAL CELLS ; HUMAN BONE-MARROW ; PROGENITOR CELLS ; IN-VITRO ; DENDRITIC CELLS ; DIFFERENTIATION ; CULTURES ; COLLECTIONS ; GROWTH ; IDENTIFICATION
英文摘要

Stem cell transplantation is a promising treatment for many conditions. Although stem cells can be isolated from many tissues, blood is the ideal source of these cells due to the ease of collection. Mesenchymal stem cells (MSCs) have been paid increased attention because of their powerful proliferation and pluripotent differentiating ability. But whether MSCs reside in blood (newborn umbilical cord blood and fetal or adult peripheral blood) is also debatable. The present study showed that MSC-like cells could be isolated and expanded from 16-26 weeks fetal blood but were not acquired efficiently from full-term infants′ umbilical cord blood (UCB). Adherent cells separated from postnatal UCB were heterogeneous in cell morphology. Their proliferation capacity was limited and they were mainly CD45(+), which indicated their haematopoietic derivation. On the contrary, MSC-like cells shared a similar phenotype to bone marrow MSCs. They were CD34(-) CD45(-) CD44(+) CD71(+) CD90(+) CD105(+). They could be induced to differentiate into osteogenic, adipogenic and neural lineage cells. Single cell clones also showed similar phenotype and differentiation ability. Our results suggest that early fetal blood is rich in MSCs but term UCB is not.

语种英语
WOS记录号WOS:000189304300013
引用统计
被引频次:57[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59995
专题北京大学基础医学院_北京大学干细胞研究中心
作者单位Peking Univ, Hlth Sci Ctr, Stem Cell Res Ctr, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yu, MJ,Xiao, ZF,Shen, L,et al. Mid-trimester fetal blood-derived adherent cells share characteristics similar to mesenchymal stem cells but full-term umbilical cord blood does not[J]. BRITISH JOURNAL OF HAEMATOLOGY,2004,124(5):666-675.
APA Yu, MJ,Xiao, ZF,Shen, L,&Li, LS.(2004).Mid-trimester fetal blood-derived adherent cells share characteristics similar to mesenchymal stem cells but full-term umbilical cord blood does not.BRITISH JOURNAL OF HAEMATOLOGY,124(5),666-675.
MLA Yu, MJ,et al."Mid-trimester fetal blood-derived adherent cells share characteristics similar to mesenchymal stem cells but full-term umbilical cord blood does not".BRITISH JOURNAL OF HAEMATOLOGY 124.5(2004):666-675.
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