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学科主题: 精神卫生
题名:
Antipsychotic Polypharmacy in Inpatients with Schizophrenia in Asia (2001-2009)
作者: Xiang, Y. -T.1,2; Wang, C. -Y.2; Si, T. -M.3; Lee, E. H. M.1; He, Y. -L.4; Ungvari, G. S.5; Chiu, H. F. K.1; Yang, S. -Y.6; Chong, M. -Y.7,8; Tan, C. -H.9; Kua, E. -H.9; Fujii, S.10; Sim, K.11; Yong, K. H.11; Trivedi, J. K.12; Chung, E. -K.13; Udomratn, P.14; Chee, K. -Y.15; Sartorius, N.16; Shinfuku, N.17
关键词: schizophrenia ; prescription patterns ; antipsychotic polypharmacy
刊名: PHARMACOPSYCHIATRY
发表日期: 2012
DOI: 10.1055/s-0031-1286345
卷: 45, 期:1, 页:7-12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: PRESCRIBING PRACTICES ; CHINESE PATIENTS ; EAST-ASIA ; DRUG-USE ; CLOZAPINE ; SINGAPORE ; UPDATE ; CARE
英文摘要:

Objective: This study aimed to identify trends in the use of antipsychotic polypharmacy (APP) and their demographic and clinical correlates in the treatment of schizophrenia in Asia between 2001 and 2009.

Method: A total of 6761 schizophrenia inpatients in 9 Asian countries and territories were examined; 2399 in 2001, 2136 in 2004, and 2226 in 2009. Patients′ socio-demographic and clinical characteristics and prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure.

Results: The proportion of APP prescription decreased from 46.8% in 2001, to 38.3% in 2004, and increased to 43.4% in 2009, with wide inter-country variations at each survey. Multiple logistic regression analysis of the whole sample revealed that patients on APP were younger, had a higher dose of antipsychotics in chlorpromazine equivalents, and more severe positive and negative symptoms. They were also more likely to receive depot and first-generation antipsychotic drugs.

Conclusions: The frequency of APP prescription varied between countries and territories, suggesting that a host of clinical and socio-cultural factors played a role in determining APP use in Asia. To resolve the discrepancy between treatment recommendation and clinical practice, regular reviews of prescription patterns are needed.

语种: 英语
所属项目编号: 81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
WOS记录号: WOS:000299909600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59997
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
2.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
5.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
6.Taipei City Hosp, Taipei, Taiwan
7.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Guishan, Taiwan
8.Chang Gung Univ, Sch Med, Guishan, Taiwan
9.Natl Univ Singapore, Singapore 117548, Singapore
10.HITS, Kobe, Hyogo, Japan
11.Inst Mental Hlth, Singapore, Singapore
12.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
13.Natl Seoul Hosp, Seoul, South Korea
14.Prince Songkla Univ, Dept Psychiat, Fac Med, Hat Yai, Thailand
15.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
16.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
17.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia

Recommended Citation:
Xiang, Y. -T.,Wang, C. -Y.,Si, T. -M.,et al. Antipsychotic Polypharmacy in Inpatients with Schizophrenia in Asia (2001-2009)[J]. PHARMACOPSYCHIATRY,2012,45(1):7-12.
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