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Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese han subjects
Li, Jun; Wang, Yufeng; Zhou, Rulun; Zhang, Haobo; Yang, Li; Wang, Bing; Faraone, Stephen V.
关键词Genetics Adhd Serotonin Transporter 5-htt Polymorphism Linkage Disequilibrium Haplotype
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2007-01-05
DOI10.1002/ajmg.b.30373
144B期:1页:14-19
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT/HYPERACTIVITY DISORDER ; DOPAMINE ; REGION ; PROMOTER ; ADHD ; SUSCEPTIBILITY ; TRANSMISSION ; FLUVOXAMINE ; 5-HTTLPR ; BOYS
英文摘要

Prior work has shown reduced serotonin transmission to be associated with impulsivity and behavioral problems. The current study assessed the association between ADHD and two variants of the serotonin transporter gene: the 44-by deletion/insertion polymorphism (5-HTTLPR) and the 17 bp-repeat polymorphism in intron 2 (STin2.VNTR). We hypothesized that ADHD phenotypes associated with impulsivity would show an association with these variants. Two-hundred and ninety-three ADHD trios were genotyped and analyzed using transmission disequilibrium test (TDT) analysis and haplotype analysis. We found no association between the STin2.VNTR and ADHD, but did find preferential transmission of the S allele of the 5-HTTLPR polymorphism (X-2 = 5.751, P = 0.016) to probands with ADHD. Haplotype analysis found the L/10 haplotype was over-transmitted (X-2 = 6.172, P = 0.013), while L/12 was under-transmitted to probands with ADHD (X-2 = 4.866, P = 0.027). (c) 2006 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000243290600004
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59999
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Med Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA
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Li, Jun,Wang, Yufeng,Zhou, Rulun,et al. Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese han subjects[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(1):14-19.
APA Li, Jun.,Wang, Yufeng.,Zhou, Rulun.,Zhang, Haobo.,Yang, Li.,...&Faraone, Stephen V..(2007).Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese han subjects.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,144B(1),14-19.
MLA Li, Jun,et al."Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese han subjects".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 144B.1(2007):14-19.
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