北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
NMDA receptor in nucleus accumbens is implicated in morphine withdrawal in rats
作者: Ji, D; Sui, ZY; Ma, YY; Luo, F; Cui, CL; Han, JS
关键词: ketamine ; morphine dependence ; NMDA receptor ; withdrawal syndrome
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2004-11-01
卷: 29, 期:11, 页:2113-2120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: LOCUS-COERULEUS NEURONS ; IN-VIVO MICRODIALYSIS ; C-FOS EXPRESSION ; OPIATE WITHDRAWAL ; PHYSICAL-DEPENDENCE ; PRECIPITATED WITHDRAWAL ; EXTENDED AMYGDALA ; KETAMINE ; ANTAGONISTS ; TOLERANCE
英文摘要:

The purpose of the present study is to elucidate whether ketamine, a non-competitive antagonist of the NMDA receptor, can suppress the morphine withdrawal syndrome in rats at a dose without affecting motor functions and to identify its site of action in the central nervous system. Rats were made dependent on morphine by multiple injections of morphine hydrochloride for 5 days. They were then given ketamine at the following doses and routes of administration: (a) intraperitoneal (i.p.) injections (2-16 mg/kg), (b) intracerebroventricular (i.c.v.) injections (4-100 mug), and (c) intra-nucleus accumbens (NAc) or intra-amygdalar microinjections (0.4-10 mug). Naloxone HCl (1 mg/kg, i.p.) was administered 3 h after the last ketamine injection to precipitate withdrawal syndrome, which was scored within a period of 30 min. Results showed that some of the precipitated withdrawal signs were dose-dependently suppressed by repeated injections of ketamine at 8 and 16 mg/kg, i.p. or 100 mug, i.c.v. Dose-dependent suppression was observed by repeated microinjections (0.4-10 mug) of ketamine to NAc, but not to amygdala. These results indicate that the NMDA receptor antagonist ketamine has the ability to suppress morphine withdrawal syndrome in experimental settings without motor interference, and NAc could be the critical CNS site mediating such effect.

语种: 英语
WOS记录号: WOS:000225538200018
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60009
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
NMDA receptor in nucleus accumbens is implicated in morphine withdrawal in rats.pdf(124KB)期刊论文出版稿限制开放 联系获取全文

作者单位: Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Minist Educ, Beijing 100083, Peoples R China

Recommended Citation:
Ji, D,Sui, ZY,Ma, YY,et al. NMDA receptor in nucleus accumbens is implicated in morphine withdrawal in rats[J]. NEUROCHEMICAL RESEARCH,2004,29(11):2113-2120.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ji, D]'s Articles
[Sui, ZY]'s Articles
[Ma, YY]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ji, D]‘s Articles
[Sui, ZY]‘s Articles
[Ma, YY]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace