IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma
Du, Ya-Bing1; Dong, Bin2; Shen, Lu-Yan1; Yan, Wan-Pu1; Dai, Liang1; Xiong, Hong-Chao1; Liang, Zhen1; Kang, Xiao-Zheng1; Qin, Bin1; Chen, Ke-Neng1
关键词HOXC6 HOXC8 IHC ESCC
刊名JOURNAL OF SURGICAL RESEARCH
2014-05-01
DOI10.1016/j.jss.2014.01.017
188期:2页:442-450
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
资助者Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Found ; New Scholar Star Program of Ministry of Education ; National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Distinguished Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Found ; New Scholar Star Program of Ministry of Education ; National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Distinguished Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China
研究领域[WOS]Surgery
关键词[WOS]PROSTATE-CANCER CELLS ; BREAST-CANCER ; HOMEOBOX GENE ; EXPRESSION ; ADENOCARCINOMA ; METASTASIS
英文摘要

Background & aim: Esophageal squamous cell carcinoma (ESCC), a common disease in China, is mainly treated surgically. We established a prospective database of patients with esophageal cancer between January 2000 and December 2010, including 486 subjects with ESCC who underwent surgical treatment. In this study, we explored the prognostic significance of the expressions of HOXC6 and HOXC8, responsible for embryonic development, by studying the specimens collected from clinical subjects during strict follow-up periods.

Materials & methods: Immunohistochemistry was used to detect the expressions of HOXC6 and HOXC8 in 274 ESCC subjects including 138 ESCC subjects treated with surgery alone and 136 ESCC subjects treated with neoadjuvant chemotherapy. Survival analysis was performed from the day of surgery to August 2013.

Results: The 5-y survival rate of the 274 ESCC subjects was 44.2%, with a median survival time of 44.12 mo. For the 274 ESCC subjects involved in the investigation of HOXC6 and HOXC8 expressions, the median survival time of subjects with high-level expressions of HOXC6 and HOXC8 was shorter than that for subjects with low-level expressions (P = 0.001, P < 0.001, respectively). Similar results were obtained from the analysis of the prognostic value of HOXC6 and HOXC8 in the group treated with surgery alone and the group treated with neoadjuvant chemotherapy. Multivariate analysis demonstrated that HOXC6 and HOXC8 expressions were independent prognostic factors in patients with ESCC.

Conclusions: The HOXC6 and HOXC8 genes can be used as prognostic markers in patients with ESCC, but prospective studies are still needed to confirm. Crown Copyright (C) 2014 Published by Elsevier Inc. All rights reserved.

语种英语
所属项目编号2009-2-17 ; 7102029 ; 2007-1023 ; 2011CB504300 ; 20130001110108 ; 81301748 ; IRT13003
资助者Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Found ; New Scholar Star Program of Ministry of Education ; National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Distinguished Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Found ; New Scholar Star Program of Ministry of Education ; National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Distinguished Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China
WOS记录号WOS:000334587500010
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60013
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp,Dept Thorac Surg 1, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Du, Ya-Bing,Dong, Bin,Shen, Lu-Yan,et al. The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma[J]. JOURNAL OF SURGICAL RESEARCH,2014,188(2):442-450.
APA Du, Ya-Bing.,Dong, Bin.,Shen, Lu-Yan.,Yan, Wan-Pu.,Dai, Liang.,...&Chen, Ke-Neng.(2014).The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma.JOURNAL OF SURGICAL RESEARCH,188(2),442-450.
MLA Du, Ya-Bing,et al."The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma".JOURNAL OF SURGICAL RESEARCH 188.2(2014):442-450.
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