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学科主题: 临床医学
题名:
The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma
作者: Du, Ya-Bing1; Dong, Bin2; Shen, Lu-Yan1; Yan, Wan-Pu1; Dai, Liang1; Xiong, Hong-Chao1; Liang, Zhen1; Kang, Xiao-Zheng1; Qin, Bin1; Chen, Ke-Neng1
关键词: HOXC6 ; HOXC8 ; IHC ; ESCC
刊名: JOURNAL OF SURGICAL RESEARCH
发表日期: 2014-05-01
DOI: 10.1016/j.jss.2014.01.017
卷: 188, 期:2, 页:442-450
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: PROSTATE-CANCER CELLS ; BREAST-CANCER ; HOMEOBOX GENE ; EXPRESSION ; ADENOCARCINOMA ; METASTASIS
英文摘要:

Background & aim: Esophageal squamous cell carcinoma (ESCC), a common disease in China, is mainly treated surgically. We established a prospective database of patients with esophageal cancer between January 2000 and December 2010, including 486 subjects with ESCC who underwent surgical treatment. In this study, we explored the prognostic significance of the expressions of HOXC6 and HOXC8, responsible for embryonic development, by studying the specimens collected from clinical subjects during strict follow-up periods.

Materials & methods: Immunohistochemistry was used to detect the expressions of HOXC6 and HOXC8 in 274 ESCC subjects including 138 ESCC subjects treated with surgery alone and 136 ESCC subjects treated with neoadjuvant chemotherapy. Survival analysis was performed from the day of surgery to August 2013.

Results: The 5-y survival rate of the 274 ESCC subjects was 44.2%, with a median survival time of 44.12 mo. For the 274 ESCC subjects involved in the investigation of HOXC6 and HOXC8 expressions, the median survival time of subjects with high-level expressions of HOXC6 and HOXC8 was shorter than that for subjects with low-level expressions (P = 0.001, P < 0.001, respectively). Similar results were obtained from the analysis of the prognostic value of HOXC6 and HOXC8 in the group treated with surgery alone and the group treated with neoadjuvant chemotherapy. Multivariate analysis demonstrated that HOXC6 and HOXC8 expressions were independent prognostic factors in patients with ESCC.

Conclusions: The HOXC6 and HOXC8 genes can be used as prognostic markers in patients with ESCC, but prospective studies are still needed to confirm. Crown Copyright (C) 2014 Published by Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2009-2-17 ; 7102029 ; 2007-1023 ; 2011CB504300 ; 20130001110108 ; 81301748 ; IRT13003
项目资助者: Beijing Academic Leaders Program ; Beijing Natural Science Foundation ; Capital Medical Developed Research Found ; New Scholar Star Program of Ministry of Education ; National Basic Research Program of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation for Distinguished Young Scholars ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China
WOS记录号: WOS:000334587500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60013
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp,Dept Thorac Surg 1, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China

Recommended Citation:
Du, Ya-Bing,Dong, Bin,Shen, Lu-Yan,et al. The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma[J]. JOURNAL OF SURGICAL RESEARCH,2014,188(2):442-450.
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