IR@PKUHSC  > 北京大学第一临床医学院  > 老年病内科
学科主题临床医学
Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress
Xue, Mei1; Liu, Meilin2; Zhu, Xinyuan2; Yang, Lin1; Miao, Yu1; Shi, Dazhuo1; Yin, Huijun1
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/482318
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
资助者National Science and Technology Major Project ; Chinese National Natural Scientific Fund ; National Science and Technology Major Project ; Chinese National Natural Scientific Fund
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]8-ISO-PROSTAGLANDIN F2-ALPHA ; HEART-FAILURE ; CELL-DEATH ; INFARCTION ; INJURY ; DISEASE ; MODEL ; OVEREXPRESSION ; CARDIOMYOCYTES ; PEROXIDATION
英文摘要

Both oxidative stress and endoplasmic reticulum stress (ERS) have been implicated in carcinogenesis and neurological diseases, while there are few reports about the mechanisms of them in the progression of acute myocardial infarction (AMI). This study examined oxidative stress and ERS in a rat model of AMI and evaluated their role in therapy by metoprolol and effective components of Panax quinquefolius and Corydalis tuber (EPC). In the present study a rat model of AMI was established by ligation of the left anterior descending coronary artery. After oral administration of metoprolol or low-to-high doses of EPC for 2 weeks, serum malondialdehyde (MDA), superoxide dismutase (SOD), and 8-iso-prostaglandin F2 alpha (8-iso-PGF2 alpha) were detected using enzyme-linked immunosorbent assay (ELISA). Quantitative real-time PCR and Western blotting were used to examine mRNA and protein expressions of the hallmarks of ERS-glucose-regulated protein-78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP). We confirmed that both metoprolol and moderate-to-high dose of EPC decreased 8-iso-PGF2 alpha serum level and downregulated the mRNA and protein expressions of GRP78 and CHOP in myocardium, while EPC also increased SOD serum level. These results indicated that metoprolol and EPC protect the myocardium by attenuating oxidative stress and ERS induced by myocardial infarction, highlighting the ERS pathways as potential therapeutic targets for AMI.

语种英语
所属项目编号2009ZX09103-441 ; 81030063 ; 81102722
资助者National Science and Technology Major Project ; Chinese National Natural Scientific Fund ; National Science and Technology Major Project ; Chinese National Natural Scientific Fund
WOS记录号WOS:000321642500001
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60015
Collection北京大学第一临床医学院_老年病内科
作者单位1.China Acad Chinese Med Sci, Xiyuan Hosp, Cardiovasc Ctr, Beijing 100091, Peoples R China
2.Peking Univ, Dept Geriatr, Hosp 1, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Xue, Mei,Liu, Meilin,Zhu, Xinyuan,et al. Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Xue, Mei.,Liu, Meilin.,Zhu, Xinyuan.,Yang, Lin.,Miao, Yu.,...&Yin, Huijun.(2013).Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Xue, Mei,et al."Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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