IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Enhanced IMP3 Expression Activates NF-kappa B Pathway and Promotes Renal Cell Carcinoma Progression
Pei, Xuelian1,2,4,7,8; Li, Muhan1,2,3; Zhan, Jun1,2,4; Yu, Yu1,2,4; Wei, Xiaofan1,2,4; Guan, Lizhao1,2,4; Aydin, Hakan5; Elson, Paul6; Zhou, Ming5; He, Huiying1,2,3; Zhang, Hongquan1,2,4
刊名PLOS ONE
2015-04-28
DOI10.1371/journal.pone.0124338
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GROWTH-FACTOR II ; PREDICT METASTASIS ; PROTEIN IMP3 ; CANCER ; PROGNOSIS ; MIGRATION ; MARKER ; ADENOCARCINOMA ; BIOMARKER ; PROLIFERATION
英文摘要

Background

Insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is expressed in metastatic and a subset of primary renal cell carcinoma (RCC). However, the role of IMP3 in RCC progression was poorly understood. We aim to uncover the mechanism of IMP3 in regulating clear cell RCC (CCRCC) progression and validate the prognostic significance of IMP3 in localized CCRCC.

Methods

Caki-1 cells stably overexpressing IMP3 and Achn cells with knockdown of IMP3 were analyzed for cell migration and invasion by Transwell assay. RNA-seq was used to profile gene expression in IMP3-expressing Caki-1 cells. A cohort of 469 localized CCRCC patients were examined for IMP3 expression by immunohistochemistry using tumor tissue array.

Results

IMP3 promoted Caki-1 cell migration and invasion, whereas knockdown of IMP3 by RNAi inhibited Achn cell migration and invasion. Enhanced IMP3 expression activated NF-kappa B pathway and through which, it functioned in promoting the RCC cell migration. IMP3 expression in localized CCRCC was found to be associated with higher nuclear grade, higher T stage, necrosis and sarcomatoid differentiation (p < 0.001). Enhanced IMP3 expression was correlated with shorter recurrence-free and overall survivals. Multivariable analysis validated IMP3 as an independent prognostic factor for localized CCRCC patients.

Conclusion

IMP3 promotes RCC cell migration and invasion by activation of NF-kappa B pathway. IMP3 is validated to be an independent prognostic marker for localized CCRCC.

语种英语
WOS记录号WOS:000353659400046
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60019
专题北京大学基础医学院_病理学系
北京大学基础医学院
北京大学药学院_药学院
作者单位1.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
2.Cleveland Clin, Inst Pathol & Lab Med, Cleveland, OH 44106 USA
3.Cleveland Clin, Dept Quantitat Hlth Sci, Cleveland, OH 44106 USA
4.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ, Hlth Sci Ctr, Beijing 100871, Peoples R China
5.Peking Univ, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100871, Peoples R China
6.Peking Univ, Dept Anat Histol & Embryol, Hlth Sci Ctr, Beijing 100871, Peoples R China
7.Shihezi Univ, Sch Med, Dept Histol & Embryol, Minist Educ, Shihezi, Xinjiang, Peoples R China
8.Shihezi Univ, Sch Med, Key Lab Xinjiang Endem & Ethn Dis, Minist Educ, Shihezi, Xinjiang, Peoples R China
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GB/T 7714
Pei, Xuelian,Li, Muhan,Zhan, Jun,et al. Enhanced IMP3 Expression Activates NF-kappa B Pathway and Promotes Renal Cell Carcinoma Progression[J]. PLOS ONE,2015,10(4).
APA Pei, Xuelian.,Li, Muhan.,Zhan, Jun.,Yu, Yu.,Wei, Xiaofan.,...&Zhang, Hongquan.(2015).Enhanced IMP3 Expression Activates NF-kappa B Pathway and Promotes Renal Cell Carcinoma Progression.PLOS ONE,10(4).
MLA Pei, Xuelian,et al."Enhanced IMP3 Expression Activates NF-kappa B Pathway and Promotes Renal Cell Carcinoma Progression".PLOS ONE 10.4(2015).
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