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学科主题: 临床医学
题名:
Biocompatibility of graphene oxide intravenously administrated in mice-effects of dose, size and exposure protocols
作者: Liu, Jia-Hui1,2,3; Wang, Tiancheng4; Wang, Haifang2; Gu, Yongen5; Xu, Yingying1; Tang, Huan1; Jia, Guang5; Liu, Yuanfang1,2
刊名: TOXICOLOGY RESEARCH
发表日期: 2015
DOI: 10.1039/c4tx00044g
卷: 4, 期:1, 页:83-91
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: WALLED CARBON NANOTUBES ; FUNCTIONALIZED GRAPHENE ; BIOMEDICAL APPLICATIONS ; PHOTOTHERMAL THERAPY ; PULMONARY TOXICITY ; CYTOTOXICITY ; DELIVERY ; SHEETS
英文摘要:

Graphene oxide (GO) shows great promise in in vivo drug delivery and therapy applications. However, several reports have reported an in vivo toxicity of GO. In this study, we found that the toxicity of GO intravenously injected into mice could be tuned by dose, size and exposure protocols of GO. The exposure to a single dose of 2.1 mg kg(-1) (single-high-dose exposure) small size GO or large size GO caused macrophage nodule formation in the lungs of the mice, and the exposure to seven repeated doses of 0.3 mg kg(-1) (multiple-low-dose exposure) large size GO also induced small macrophage nodule formation, serious lymphocyte infiltration around the bronchioles in the lungs of the mice, and even death of the mice. Nephritic inflammatory reactions were also observed after the multiple-low-dose exposure to large size GO. However, no obvious lung toxicity but hepatic inflammatory infiltration was observed after the exposure to multiple-low-dose small size GO. GO accumulation in the macrophage nodules was verified by Raman mapping. These findings will benefit the applications of GO in the future, especially in biomedical fields.

语种: 英语
WOS记录号: WOS:000346164200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60023
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
3.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China
4.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100083, Peoples R China
5.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Jia-Hui,Wang, Tiancheng,Wang, Haifang,et al. Biocompatibility of graphene oxide intravenously administrated in mice-effects of dose, size and exposure protocols[J]. TOXICOLOGY RESEARCH,2015,4(1):83-91.
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