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学科主题临床医学
Biocompatibility of graphene oxide intravenously administrated in mice-effects of dose, size and exposure protocols
Liu, Jia-Hui1,2,3; Wang, Tiancheng4; Wang, Haifang2; Gu, Yongen5; Xu, Yingying1; Tang, Huan1; Jia, Guang5; Liu, Yuanfang1,2
刊名TOXICOLOGY RESEARCH
2015
DOI10.1039/c4tx00044g
4期:1页:83-91
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]WALLED CARBON NANOTUBES ; FUNCTIONALIZED GRAPHENE ; BIOMEDICAL APPLICATIONS ; PHOTOTHERMAL THERAPY ; PULMONARY TOXICITY ; CYTOTOXICITY ; DELIVERY ; SHEETS
英文摘要

Graphene oxide (GO) shows great promise in in vivo drug delivery and therapy applications. However, several reports have reported an in vivo toxicity of GO. In this study, we found that the toxicity of GO intravenously injected into mice could be tuned by dose, size and exposure protocols of GO. The exposure to a single dose of 2.1 mg kg(-1) (single-high-dose exposure) small size GO or large size GO caused macrophage nodule formation in the lungs of the mice, and the exposure to seven repeated doses of 0.3 mg kg(-1) (multiple-low-dose exposure) large size GO also induced small macrophage nodule formation, serious lymphocyte infiltration around the bronchioles in the lungs of the mice, and even death of the mice. Nephritic inflammatory reactions were also observed after the multiple-low-dose exposure to large size GO. However, no obvious lung toxicity but hepatic inflammatory infiltration was observed after the exposure to multiple-low-dose small size GO. GO accumulation in the macrophage nodules was verified by Raman mapping. These findings will benefit the applications of GO in the future, especially in biomedical fields.

语种英语
WOS记录号WOS:000346164200008
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60023
专题北京大学第三临床医学院
北京大学公共卫生学院_公共卫生学院
北京大学第二临床医学院_放射科
北京大学第三临床医学院_护理部
作者单位1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
3.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China
4.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100083, Peoples R China
5.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
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GB/T 7714
Liu, Jia-Hui,Wang, Tiancheng,Wang, Haifang,et al. Biocompatibility of graphene oxide intravenously administrated in mice-effects of dose, size and exposure protocols[J]. TOXICOLOGY RESEARCH,2015,4(1):83-91.
APA Liu, Jia-Hui.,Wang, Tiancheng.,Wang, Haifang.,Gu, Yongen.,Xu, Yingying.,...&Liu, Yuanfang.(2015).Biocompatibility of graphene oxide intravenously administrated in mice-effects of dose, size and exposure protocols.TOXICOLOGY RESEARCH,4(1),83-91.
MLA Liu, Jia-Hui,et al."Biocompatibility of graphene oxide intravenously administrated in mice-effects of dose, size and exposure protocols".TOXICOLOGY RESEARCH 4.1(2015):83-91.
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