|Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults|
|Jiang Hong1; Zhao Min2; Pan Bai-shen3; Zhang Jie4; Peng Ming-ting5; Huang Xian-zhang6; Hao Xiao-ke7; Wang Lan-lan1; Zhang Xin2; Guo Wei3; Qiao Rui4; Chen Wen-xiang5; Wu Xin-zhong6; Ma Yue-yun7; Shang Hong2|
|关键词||reference intervals platelet indices PLT count MPV PDW P-LCR Pct|
|刊名||JOURNAL OF CLINICAL LABORATORY ANALYSIS|
|WOS标题词||Science & Technology|
|类目[WOS]||Medical Laboratory Technology|
|研究领域[WOS]||Medical Laboratory Technology|
BackgroundReference intervals are important for interpretation of clinical laboratory tests. The platelet (PLT) indices such as the mean platelet volume (MPV) and platelet distribution width (PDW) are newer hematological parameters, which have been recently reported as clinically valuable biomarkers. However, there are not many studies that have estimated the reference intervals for these parameters in healthy Chinese Han adults.
ObjectiveThe objectives of this study were to establish reference values of PLT indices [including PLT count, MPV, PDW, platelet-large cell ratio (P-LCR), and plateletcrit (Pct)] for healthy Chinese Han adults. We also aimed to determine the region-based differences of PLT indices in China.
MethodsA total of 4,642 volunteers with a mean age of 43 were recruited from six regions of China. PLT indices were performed on Sysmex XE-2100 hematology analyzers, whose traceability was well verified.
ResultsThere were significant region-based differences for all PLT indices. Reference people in Chengdu had the lowest mean PLT count and Pct, but the highest MPV, PDW, and P-LCR among the six regions. Therefore, we derived the reference intervals in Chinese Han population excluding Chengdu reference people for PLT indices as PLT count: (127-341) x 10(9)/l; MPV: (9.20-13.30) fl; PDW: 9.90-19.00%; P-LCR: 18.10-52.00%; Pct: 16.00-41.00%.
ConclusionsRegion-specific reference intervals are essential as there were statistically significant region-related differences in the PLT parameters. The reference intervals established in this study differed from the existing reference values. Chengdu region may need proper specific reference ranges, which apply to their people, for all PLT parameters.
|资助机构||Ministry of Health, China|
|作者单位||1.Beijing Hosp, Natl Ctr Clin Labs, Beijing, Peoples R China|
2.Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu 610064, Peoples R China
3.China Med Univ, Dept Lab Med, Affiliated Hosp 1, Shenyang, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Dept Clin Lab Med, Shanghai 200433, Peoples R China
5.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100871, Peoples R China
6.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Lab Sci, Guangzhou, Guangdong, Peoples R China
7.Fourth Mil Med Univ, Dept Clin Lab Med, Xijing Hosp, Xian 710032, Peoples R China
|Jiang Hong,Zhao Min,Pan Bai-shen,et al. Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2015,29(1):21-27.|
|APA||Jiang Hong.,Zhao Min.,Pan Bai-shen.,Zhang Jie.,Peng Ming-ting.,...&Shang Hong.(2015).Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults.JOURNAL OF CLINICAL LABORATORY ANALYSIS,29(1),21-27.|
|MLA||Jiang Hong,et al."Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults".JOURNAL OF CLINICAL LABORATORY ANALYSIS 29.1(2015):21-27.|