北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults
作者: Jiang Hong1; Zhao Min2; Pan Bai-shen3; Zhang Jie4; Peng Ming-ting5; Huang Xian-zhang6; Hao Xiao-ke7; Wang Lan-lan1; Zhang Xin2; Guo Wei3; Qiao Rui4; Chen Wen-xiang5; Wu Xin-zhong6; Ma Yue-yun7; Shang Hong2
关键词: reference intervals ; platelet indices ; PLT count ; MPV ; PDW ; P-LCR ; Pct
刊名: JOURNAL OF CLINICAL LABORATORY ANALYSIS
发表日期: 2015
DOI: 10.1002/jcla.21721
卷: 29, 期:1, 页:21-27
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: POPULATION
英文摘要:

BackgroundReference intervals are important for interpretation of clinical laboratory tests. The platelet (PLT) indices such as the mean platelet volume (MPV) and platelet distribution width (PDW) are newer hematological parameters, which have been recently reported as clinically valuable biomarkers. However, there are not many studies that have estimated the reference intervals for these parameters in healthy Chinese Han adults.

ObjectiveThe objectives of this study were to establish reference values of PLT indices [including PLT count, MPV, PDW, platelet-large cell ratio (P-LCR), and plateletcrit (Pct)] for healthy Chinese Han adults. We also aimed to determine the region-based differences of PLT indices in China.

MethodsA total of 4,642 volunteers with a mean age of 43 were recruited from six regions of China. PLT indices were performed on Sysmex XE-2100 hematology analyzers, whose traceability was well verified.

ResultsThere were significant region-based differences for all PLT indices. Reference people in Chengdu had the lowest mean PLT count and Pct, but the highest MPV, PDW, and P-LCR among the six regions. Therefore, we derived the reference intervals in Chinese Han population excluding Chengdu reference people for PLT indices as PLT count: (127-341) x 10(9)/l; MPV: (9.20-13.30) fl; PDW: 9.90-19.00%; P-LCR: 18.10-52.00%; Pct: 16.00-41.00%.

ConclusionsRegion-specific reference intervals are essential as there were statistically significant region-related differences in the PLT parameters. The reference intervals established in this study differed from the existing reference values. Chengdu region may need proper specific reference ranges, which apply to their people, for all PLT parameters.

语种: 英语
项目资助者: Ministry of Health, China
WOS记录号: WOS:000347974100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60027
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Hosp, Natl Ctr Clin Labs, Beijing, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu 610064, Peoples R China
3.China Med Univ, Dept Lab Med, Affiliated Hosp 1, Shenyang, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Dept Clin Lab Med, Shanghai 200433, Peoples R China
5.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100871, Peoples R China
6.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Lab Sci, Guangzhou, Guangdong, Peoples R China
7.Fourth Mil Med Univ, Dept Clin Lab Med, Xijing Hosp, Xian 710032, Peoples R China

Recommended Citation:
Jiang Hong,Zhao Min,Pan Bai-shen,et al. Investigation on Reference Intervals and Regional Differences of Platelet Indices in Healthy Chinese Han Adults[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2015,29(1):21-27.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jiang Hong]'s Articles
[Zhao Min]'s Articles
[Pan Bai-shen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jiang Hong]‘s Articles
[Zhao Min]‘s Articles
[Pan Bai-shen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace