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学科主题: 临床医学
题名:
Relationship Between LAPTM4B Gene Polymorphism and Susceptibility of Malignant Melanoma in Chinese Patients
作者: Zhang, Meng1; Zhou, Rouli2; Xu, Jianjun1; Zhang, Qingyun1
刊名: Translational Oncology
发表日期: 2014-10-01
DOI: 10.1016/j.tranon.2014.07.001
卷: 7, 期:5, 页:638-643
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; CANCER ; OVEREXPRESSION ; ASSOCIATION ; RESISTANCE ; AUTOPHAGY ; TOLERANCE ; STRESS
英文摘要:

Lysosomal-associated protein transmembrane 4 beta (LAPTM4B) is known as an oncogene associated with many human malignant tumors. There are two alleles of the gene, LAPTM4B*1 and LAPTM4B*2. Previous studies have shown that LAPTM4B polymorphism contributes to the risk of many cancers. This case-control study was to investigate the relationship between LAPTM4B gene polymorphism and susceptibility of malignant melanoma. The genotypes of LAPTM4B were determined in 617 control subjects and 220 patients with malignant melanoma by utilizing polymerase chain reaction based on specific primers. The genotypic distribution of LAPTM4B and Hardy-Weinberg equilibrium were analyzed by chi(2) test. Odds ratio and 95% confidence interval was calculated by unconditional logistic regression. The distributions of LAPTM4B genotypes were significantly different between melanoma patients (45.9% for *1/1, 46.4% for *1/2 and 7.7 for *2/2) and controls (54.5% for *1/1, 39.9% for *1/2 and 5.7 for *2/2). LAPTM4B *1/2 and LAPTM4B *2/2 had a 1.396-fold and 1.619-fold higher risk for melanoma occurrence than *1/1, and subjects with LAPTM4B*2 have a 1.308-fold higher risk than LAPTM4B*1 carriers. No association between LAPTM4B genotypes and gender, age, subtype, Clark level of invasion, Breslowthickness, ulceration, clinical stage, and C-KIT, BRAF gene mutation status was observed. LAPTM4B*2 is associated with the high risk of malignant melanoma and carrying LAPTM4B*2 may be a susceptible factor to Chinese melanoma patients.

语种: 英语
所属项目编号: 81071422
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000348837100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60031
Appears in Collections:北京大学临床肿瘤学院_临床实验室_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Clin Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Meng,Zhou, Rouli,Xu, Jianjun,et al. Relationship Between LAPTM4B Gene Polymorphism and Susceptibility of Malignant Melanoma in Chinese Patients[J]. Translational Oncology,2014,7(5):638-643.
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