IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Genomewide Analysis of Rat Periaqueductal Gray-Dorsal Horn Reveals Time-, Region- and Frequency-Specific mRNA Expression Changes in Response to Electroacupuncture Stimulation
Wang, Ke1,4; Xiang, Xiao-Hui2,3; Qiao, Nan5; Qi, Jun-Yi1; Lin, Li-Bo1; Zhang, Rong2,3; Shou, Xiao-jing2,3; Ping, Xing-Jie2,3; Han, Ji-Sheng2,3; Han, Jing-Dong5; Zhao, Guo-Ping1; Cui, Cai-Lian2,3
刊名SCIENTIFIC REPORTS
2014-10-27
DOI10.1038/srep06713
4期:Oct 27
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Development of Chinese medicine in Shanghai ; National Basic Research Program of China ; National Natural Science Foundation of China ; Development of Chinese medicine in Shanghai
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ELECTRICAL ACUPOINT STIMULATION ; TAIL-FLICK TEST ; GENE-EXPRESSION ; NEUROPATHIC PAIN ; ACUPUNCTURE ANESTHESIA ; DISTINCTIVE CHANGES ; ANALGESIA ; RECEPTOR ; MODEL ; SENSITIVITY
英文摘要

Electroacupuncture (EA) has been widely applied for illness prevention, treatment or rehabilitation in the clinic, especially for pain management. However, the molecular events that induce these changes remain largely uncharacterized. The periaqueductal gray (PAG) and the spinal dorsal horn (DH) have been verified as two critical regions in the response to EA stimulation in EA analgesia. In this study, a genetic screen was conducted to delineate the gene expression profile in the PAG-DH regions of rats to explore the molecular events of the analgesic effect induced by low-frequency (2-Hz) and high-frequency (100-Hz) EAs. Microarray analysis at two different time points after EA stimulation revealed time-, region- and frequency-specific gene expression changes. These expression differences suggested that modulation of neural-immune interaction in the central nervous system played an important role during EA analgesia. Furthermore, low-frequency EA could regulate gene expression to a greater degree than high-frequency EA. Altogether, the present study offers, for the first time, a characterized transcriptional response pattern in the PAG-DH regions followed by EA stimulation and, thus, provides a solid experimental framework for future in-depth analysis of the mechanisms underlying EA-induced effects.

语种英语
所属项目编号973-2013CB531905 ; 973-2013CB531901 ; 81202767 ; ZYSNXD-CC-ZDYJ 014
资助者National Basic Research Program of China ; National Natural Science Foundation of China ; Development of Chinese medicine in Shanghai ; National Basic Research Program of China ; National Natural Science Foundation of China ; Development of Chinese medicine in Shanghai
WOS记录号WOS:000343978300001
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60037
Collection北京大学基础医学院_神经生物学系
作者单位1.Chinese Natl Human Genome Ctr shanghai, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai 201203, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Lab Integrat Med Surg, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Max Planck Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Wang, Ke,Xiang, Xiao-Hui,Qiao, Nan,et al. Genomewide Analysis of Rat Periaqueductal Gray-Dorsal Horn Reveals Time-, Region- and Frequency-Specific mRNA Expression Changes in Response to Electroacupuncture Stimulation[J]. SCIENTIFIC REPORTS,2014,4(Oct 27).
APA Wang, Ke.,Xiang, Xiao-Hui.,Qiao, Nan.,Qi, Jun-Yi.,Lin, Li-Bo.,...&Cui, Cai-Lian.(2014).Genomewide Analysis of Rat Periaqueductal Gray-Dorsal Horn Reveals Time-, Region- and Frequency-Specific mRNA Expression Changes in Response to Electroacupuncture Stimulation.SCIENTIFIC REPORTS,4(Oct 27).
MLA Wang, Ke,et al."Genomewide Analysis of Rat Periaqueductal Gray-Dorsal Horn Reveals Time-, Region- and Frequency-Specific mRNA Expression Changes in Response to Electroacupuncture Stimulation".SCIENTIFIC REPORTS 4.Oct 27(2014).
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