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学科主题: 临床医学
题名:
Pathology of urethral fibromuscular system related to parturition-induced stress urinary incontinence and TGF-beta 1/Smad pathway
作者: Li, Guang-Yong; Cui, Wan-Shou; Zhou, Feng; Gao, Zhe-Zhu; Xin, Hua; Liu, Tao; Li, Wei-Ren; Gong, Yan-Qing; Bai, Guang-Yi; Guo, Ying-Lu; Xin, Zhong-Cheng
关键词: Extracellular matrix ; MMP-9 ; Stress urinary incontinence ; Smad2 ; TGF-beta 1
刊名: MOLECULAR AND CELLULAR BIOCHEMISTRY
发表日期: 2012-05-01
DOI: 10.1007/s11010-012-1234-x
卷: 364, 期:1-2, 页:329-335
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: SIMULATED BIRTH TRAUMA ; PELVIC ORGAN PROLAPSE ; CONTINENCE MECHANISM ; EXTRACELLULAR-MATRIX ; STEM-CELLS ; RAT MODEL ; PREGNANCY ; TISSUE ; WOMEN ; PROLIFERATION
英文摘要:

To study pathological changes of fibromuscular system and the role of TGF-beta 1/Smad pathway in the urethra of a parturition-induced stress urinary incontinence (SUI) rat model. Twenty-eight 8-week-old Sprague-Dawley female rats at gestational day 16 were used and randomized into two groups: sham group and SUI group. After delivery, rats in the SUI group underwent postpartum vaginal balloon dilation and bilateral ovariectomy. 1 month after ovariectomy, urodynamics was assessed. Histological examination (Masson′s trichrome stain, picrosirius red stain, Hart′s elastin stain, Gordon & Sweet′s stain, and immunohistochemical stain) and Western blot were performed on urethral tissues. Both leak point pressure and maximal bladder capacity were significantly decreased in the balloon-injured ovariectomized rats, compared with the sham rats. Muscle was significantly decreased in the urethra of SUI rats compare with sham rats. Collagen I/III and reticular fibers from SUI group were also significantly lower than sham group. Meanwhile, elastic fibers and reticular fibers showed fragmentation and disorganization indicating impairment in the fibromuscular system in SUI rats. TGF-beta 1, MMP-9, and phosphorylated Smad2 (p-Smad2) were expressed significantly higher in SUI than in sham rats. Simulated birth trauma and menopause induced an upregulation of the TGF-beta 1/Smad pathway and impairment of the fibromuscular system in the urethra.

语种: 英语
所属项目编号: Z080507030808011 ; 30972993
项目资助者: Peking Natural Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000303458300035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60038
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: Peking Univ, Androl Ctr, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Li, Guang-Yong,Cui, Wan-Shou,Zhou, Feng,et al. Pathology of urethral fibromuscular system related to parturition-induced stress urinary incontinence and TGF-beta 1/Smad pathway[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2012,364(1-2):329-335.
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