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Pathology of urethral fibromuscular system related to parturition-induced stress urinary incontinence and TGF-beta 1/Smad pathway
Li, Guang-Yong; Cui, Wan-Shou; Zhou, Feng; Gao, Zhe-Zhu; Xin, Hua; Liu, Tao; Li, Wei-Ren; Gong, Yan-Qing; Bai, Guang-Yi; Guo, Ying-Lu; Xin, Zhong-Cheng
关键词Extracellular matrix MMP-9 Stress urinary incontinence Smad2 TGF-beta 1
刊名MOLECULAR AND CELLULAR BIOCHEMISTRY
2012-05-01
DOI10.1007/s11010-012-1234-x
364期:1-2页:329-335
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]SIMULATED BIRTH TRAUMA ; PELVIC ORGAN PROLAPSE ; CONTINENCE MECHANISM ; EXTRACELLULAR-MATRIX ; STEM-CELLS ; RAT MODEL ; PREGNANCY ; TISSUE ; WOMEN ; PROLIFERATION
英文摘要

To study pathological changes of fibromuscular system and the role of TGF-beta 1/Smad pathway in the urethra of a parturition-induced stress urinary incontinence (SUI) rat model. Twenty-eight 8-week-old Sprague-Dawley female rats at gestational day 16 were used and randomized into two groups: sham group and SUI group. After delivery, rats in the SUI group underwent postpartum vaginal balloon dilation and bilateral ovariectomy. 1 month after ovariectomy, urodynamics was assessed. Histological examination (Masson′s trichrome stain, picrosirius red stain, Hart′s elastin stain, Gordon & Sweet′s stain, and immunohistochemical stain) and Western blot were performed on urethral tissues. Both leak point pressure and maximal bladder capacity were significantly decreased in the balloon-injured ovariectomized rats, compared with the sham rats. Muscle was significantly decreased in the urethra of SUI rats compare with sham rats. Collagen I/III and reticular fibers from SUI group were also significantly lower than sham group. Meanwhile, elastic fibers and reticular fibers showed fragmentation and disorganization indicating impairment in the fibromuscular system in SUI rats. TGF-beta 1, MMP-9, and phosphorylated Smad2 (p-Smad2) were expressed significantly higher in SUI than in sham rats. Simulated birth trauma and menopause induced an upregulation of the TGF-beta 1/Smad pathway and impairment of the fibromuscular system in the urethra.

语种英语
WOS记录号WOS:000303458300035
项目编号Z080507030808011 ; 30972993
资助机构Peking Natural Science Foundation ; National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60038
专题北京大学第一临床医学院_男科中心
北京大学第一临床医学院_北京大学泌尿外科研究所
作者单位Peking Univ, Androl Ctr, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li, Guang-Yong,Cui, Wan-Shou,Zhou, Feng,et al. Pathology of urethral fibromuscular system related to parturition-induced stress urinary incontinence and TGF-beta 1/Smad pathway[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2012,364(1-2):329-335.
APA Li, Guang-Yong.,Cui, Wan-Shou.,Zhou, Feng.,Gao, Zhe-Zhu.,Xin, Hua.,...&Xin, Zhong-Cheng.(2012).Pathology of urethral fibromuscular system related to parturition-induced stress urinary incontinence and TGF-beta 1/Smad pathway.MOLECULAR AND CELLULAR BIOCHEMISTRY,364(1-2),329-335.
MLA Li, Guang-Yong,et al."Pathology of urethral fibromuscular system related to parturition-induced stress urinary incontinence and TGF-beta 1/Smad pathway".MOLECULAR AND CELLULAR BIOCHEMISTRY 364.1-2(2012):329-335.
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