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Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica
Xie, Bai-Bo1,2; Liu, Hai-Yang1; Ni, Wei1; Chen, Chang-Xiang1
关键词Ypsilandra thibetica Liliaceae Spirostanol saponins Ypsilandrosides C-G Cytotoxicity Antifungal activity
刊名STEROIDS
2009-11-04
DOI10.1016/j.steroids.2009.07.001
74期:12页:950-955
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
资助者West Light Foundation of the Chinese Academy of Sciences ; State Key Laboratory of Phytochemistry and Plant Resources in West China ; Germplasm Bank of Wild Species and CAS Innovation Program of Kunming Institute of Botany ; West Light Foundation of the Chinese Academy of Sciences ; State Key Laboratory of Phytochemistry and Plant Resources in West China ; Germplasm Bank of Wild Species and CAS Innovation Program of Kunming Institute of Botany
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]STEROIDAL SAPONINS ; NMR-SPECTROSCOPY
英文摘要

A further phytochemical investigation on the whole plants of Ypsilandra thibetica yielded one sapogenin and 12 spirostanol saponins. Five of these are new compounds, designated as ypsilandrosides C-G (2-6). Their structures were determined by detailed spectroscopic analysis, including extensive 1D and 2D NMR data, and by the result of a hydrolytic reaction. Compounds 2-5 were rare steroidal saponins that an apiofuranosyl unit was directly linked at C-3 of the aglycone. Selected spirostanol saponins (2-6, 9) were tested for their cytotoxic activities against K562, SPC-A-1, BGC-823, Eca-109, and AGS cell lines. Compounds 6 and 9 showed moderate inhibitory activity against all five cell lines. The antifungal properties of the new spirostanol saponins (2-6) against Candida albicans were also determined. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
所属项目编号2908025712W1 ; 540806321211
资助者West Light Foundation of the Chinese Academy of Sciences ; State Key Laboratory of Phytochemistry and Plant Resources in West China ; Germplasm Bank of Wild Species and CAS Innovation Program of Kunming Institute of Botany ; West Light Foundation of the Chinese Academy of Sciences ; State Key Laboratory of Phytochemistry and Plant Resources in West China ; Germplasm Bank of Wild Species and CAS Innovation Program of Kunming Institute of Botany
WOS记录号WOS:000270759500012
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60041
Collection北京大学药学院
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Xie, Bai-Bo,Liu, Hai-Yang,Ni, Wei,et al. Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica[J]. STEROIDS,2009,74(12):950-955.
APA Xie, Bai-Bo,Liu, Hai-Yang,Ni, Wei,&Chen, Chang-Xiang.(2009).Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica.STEROIDS,74(12),950-955.
MLA Xie, Bai-Bo,et al."Ypsilandrosides C-G, five new spirostanol saponins from Ypsilandra thibetica".STEROIDS 74.12(2009):950-955.
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