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Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population
Wang, Bing1; Xu, Jianjun1; Zhou, Rouli2; Zhang, Qingyun1
关键词Laptm4b Gene Polymorphism Susceptibility Nasopharyngeal Carcinoma
刊名MEDICAL ONCOLOGY
2013-03-01
DOI10.1007/s12032-013-0470-6
30期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]INDEPENDENT PROGNOSTIC MARKER ; HEPATOCELLULAR-CARCINOMA ; RISK-FACTORS ; CANCER SUSCEPTIBILITY ; OVEREXPRESSION ; PROGRESSION ; EXPRESSION ; AUTOPHAGY ; TOLERANCE ; SHANGHAI
英文摘要

Lysosome-associated protein transmembrane-4 beta (LAPTM4B) is a novel cancer-related gene. It has two alleles designated LAPTM4B*1 and LAPTM4B*2. Previous studies have revealed that LAPTM4B polymorphisms contribute to the risk of many cancers. The aim of this study was to investigate the association between different LAPTM4B alleles and the risk of nasopharyngeal carcinoma (NPC), one of the most common cancers in southern China. Using polymerase chain reaction (PCR) in a case-control study, we detected the LAPTM4B genotype in peripheral blood samples from 134 patients with NPC and 327 control subjects. The chi-square test was used to analyze differences of categorical variables and Hardy-Weinberg equilibrium. Odds ratios and 95 % CI were computed using an unconditional logistic regression model. The frequency of allele *2 was 26.87 % in the NPC group, which was not significantly different from that of the control group (27.98 %, P = 0.867). Using the LAPTM4B*1/1 genotype as a reference, we found that the *1/2, *2/2 and *1/2 + *2/2 genotype were also not associated with the risk of NPC. No association was observed between LAPTM4B gene polymorphisms and the risk of NPC adjusted by gender and age. The results of our study indicated that the polymorphism of LAPTM4B gene did not influence the susceptibility of NPC in the Chinese population. Large-scale studies are needed to confirm our findings.

语种英语
WOS记录号WOS:000316800800146
项目编号81071422
资助机构National Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60053
专题北京大学临床肿瘤学院_临床实验室
北京大学临床肿瘤学院_检验科
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Clin Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Wang, Bing,Xu, Jianjun,Zhou, Rouli,et al. Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population[J]. MEDICAL ONCOLOGY,2013,30(1).
APA Wang, Bing,Xu, Jianjun,Zhou, Rouli,&Zhang, Qingyun.(2013).Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population.MEDICAL ONCOLOGY,30(1).
MLA Wang, Bing,et al."Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population".MEDICAL ONCOLOGY 30.1(2013).
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