北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 临床实验室  > 期刊论文
学科主题: 临床医学
题名:
Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population
作者: Wang, Bing1; Xu, Jianjun1; Zhou, Rouli2; Zhang, Qingyun1
关键词: LAPTM4B ; Gene polymorphism ; Susceptibility ; Nasopharyngeal carcinoma
刊名: MEDICAL ONCOLOGY
发表日期: 2013-03-01
DOI: 10.1007/s12032-013-0470-6
卷: 30, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: INDEPENDENT PROGNOSTIC MARKER ; HEPATOCELLULAR-CARCINOMA ; RISK-FACTORS ; CANCER SUSCEPTIBILITY ; OVEREXPRESSION ; PROGRESSION ; EXPRESSION ; AUTOPHAGY ; TOLERANCE ; SHANGHAI
英文摘要:

Lysosome-associated protein transmembrane-4 beta (LAPTM4B) is a novel cancer-related gene. It has two alleles designated LAPTM4B*1 and LAPTM4B*2. Previous studies have revealed that LAPTM4B polymorphisms contribute to the risk of many cancers. The aim of this study was to investigate the association between different LAPTM4B alleles and the risk of nasopharyngeal carcinoma (NPC), one of the most common cancers in southern China. Using polymerase chain reaction (PCR) in a case-control study, we detected the LAPTM4B genotype in peripheral blood samples from 134 patients with NPC and 327 control subjects. The chi-square test was used to analyze differences of categorical variables and Hardy-Weinberg equilibrium. Odds ratios and 95 % CI were computed using an unconditional logistic regression model. The frequency of allele *2 was 26.87 % in the NPC group, which was not significantly different from that of the control group (27.98 %, P = 0.867). Using the LAPTM4B*1/1 genotype as a reference, we found that the *1/2, *2/2 and *1/2 + *2/2 genotype were also not associated with the risk of NPC. No association was observed between LAPTM4B gene polymorphisms and the risk of NPC adjusted by gender and age. The results of our study indicated that the polymorphism of LAPTM4B gene did not influence the susceptibility of NPC in the Chinese population. Large-scale studies are needed to confirm our findings.

语种: 英语
所属项目编号: 81071422
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000316800800146
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60053
Appears in Collections:北京大学临床肿瘤学院_临床实验室_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Clin Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100142, Peoples R China

Recommended Citation:
Wang, Bing,Xu, Jianjun,Zhou, Rouli,et al. Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population[J]. MEDICAL ONCOLOGY,2013,30(1).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Bing]'s Articles
[Xu, Jianjun]'s Articles
[Zhou, Rouli]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Bing]‘s Articles
[Xu, Jianjun]‘s Articles
[Zhou, Rouli]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace