学科主题 | 临床医学 |
Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis | |
Ren, Q.1; Xiao, J.2; Han, X.1; Luo, Y.1; Yang, W.2; Ji, L.1 | |
关键词 | diabetes TCF7L2 rs290487 |
刊名 | EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
![]() |
2013-10-01 | |
DOI | 10.1055/s-0033-1347199 |
卷 | 121期:9页:526-530 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Endocrinology & Metabolism |
研究领域[WOS] | Endocrinology & Metabolism |
关键词[WOS] | JAPANESE POPULATION ; INSULIN-RESISTANCE ; POLYMORPHISMS ; RISK ; SUSCEPTIBILITY ; VARIANTS ; REPLICATION ; WOMEN ; MEN |
英文摘要 | Aims: rs290487 in TCF7L2 was originally identified to be associated with type 2 diabetes in Taiwan Chinese population. However, discrepancies were noted in subsequent replicated studies. So the aim of this study is to investigate the effect of rs290487 in TCF7L2 on genetic susceptibility of type 2 diabetes in a large sample of Chinese population. Results: In meta analysis of 9 studies with 9 422 cases and 8 585 control subjects, no association was found between rs290487 and type 2 diabetes in China (OR = 1.06, 95 % confidence interval (CI), 0.96-1.17, p = 0.19). In case control study, rs290487 was genotyped in 5 151 diabetic patients and 4 650 non-diabetic controls. After adjusting for sex, age and BMI, and using an additive genetic model, logistic regression analysis revealed no association between rs290487 and type 2 diabetes (OR = 1.015, 95 % CI 0.949-1.087, p = 0.662). No association was found between rs290487 and type 2 diabetes in northern and southern Chinese population separately. Conclusions: In summary, we have found no association between rs290487 and type 2 diabetes in Chinese population. This SNP is unlikely an influential genetic variant with type 2 diabetes in Chinese population. |
语种 | 英语 |
WOS记录号 | WOS:000325635000003 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/60054 |
Collection | 北京大学第二临床医学院 |
作者单位 | 1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Peking Univ Diabet Ctr, Beijing 100044, Peoples R China 2.China Japan Friendship Hosp, Beijing, Peoples R China |
Recommended Citation GB/T 7714 | Ren, Q.,Xiao, J.,Han, X.,et al. Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis[J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,2013,121(9):526-530. |
APA | Ren, Q.,Xiao, J.,Han, X.,Luo, Y.,Yang, W.,&Ji, L..(2013).Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis.EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,121(9),526-530. |
MLA | Ren, Q.,et al."Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis".EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES 121.9(2013):526-530. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment