北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis
作者: Ren, Q.1; Xiao, J.2; Han, X.1; Luo, Y.1; Yang, W.2; Ji, L.1
关键词: diabetes ; TCF7L2 ; rs290487
刊名: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
发表日期: 2013-10-01
DOI: 10.1055/s-0033-1347199
卷: 121, 期:9, 页:526-530
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: JAPANESE POPULATION ; INSULIN-RESISTANCE ; POLYMORPHISMS ; RISK ; SUSCEPTIBILITY ; VARIANTS ; REPLICATION ; WOMEN ; MEN
英文摘要:

Aims: rs290487 in TCF7L2 was originally identified to be associated with type 2 diabetes in Taiwan Chinese population. However, discrepancies were noted in subsequent replicated studies. So the aim of this study is to investigate the effect of rs290487 in TCF7L2 on genetic susceptibility of type 2 diabetes in a large sample of Chinese population.

Results: In meta analysis of 9 studies with 9 422 cases and 8 585 control subjects, no association was found between rs290487 and type 2 diabetes in China (OR = 1.06, 95 % confidence interval (CI), 0.96-1.17, p = 0.19). In case control study, rs290487 was genotyped in 5 151 diabetic patients and 4 650 non-diabetic controls. After adjusting for sex, age and BMI, and using an additive genetic model, logistic regression analysis revealed no association between rs290487 and type 2 diabetes (OR = 1.015, 95 % CI 0.949-1.087, p = 0.662). No association was found between rs290487 and type 2 diabetes in northern and southern Chinese population separately.

Conclusions: In summary, we have found no association between rs290487 and type 2 diabetes in Chinese population. This SNP is unlikely an influential genetic variant with type 2 diabetes in Chinese population.

语种: 英语
WOS记录号: WOS:000325635000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60054
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Peking Univ Diabet Ctr, Beijing 100044, Peoples R China
2.China Japan Friendship Hosp, Beijing, Peoples R China

Recommended Citation:
Ren, Q.,Xiao, J.,Han, X.,et al. Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis[J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,2013,121(9):526-530.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ren, Q.]'s Articles
[Xiao, J.]'s Articles
[Han, X.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ren, Q.]‘s Articles
[Xiao, J.]‘s Articles
[Han, X.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace