IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis
Ren, Q.1; Xiao, J.2; Han, X.1; Luo, Y.1; Yang, W.2; Ji, L.1
关键词diabetes TCF7L2 rs290487
刊名EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
2013-10-01
DOI10.1055/s-0033-1347199
121期:9页:526-530
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]JAPANESE POPULATION ; INSULIN-RESISTANCE ; POLYMORPHISMS ; RISK ; SUSCEPTIBILITY ; VARIANTS ; REPLICATION ; WOMEN ; MEN
英文摘要

Aims: rs290487 in TCF7L2 was originally identified to be associated with type 2 diabetes in Taiwan Chinese population. However, discrepancies were noted in subsequent replicated studies. So the aim of this study is to investigate the effect of rs290487 in TCF7L2 on genetic susceptibility of type 2 diabetes in a large sample of Chinese population.

Results: In meta analysis of 9 studies with 9 422 cases and 8 585 control subjects, no association was found between rs290487 and type 2 diabetes in China (OR = 1.06, 95 % confidence interval (CI), 0.96-1.17, p = 0.19). In case control study, rs290487 was genotyped in 5 151 diabetic patients and 4 650 non-diabetic controls. After adjusting for sex, age and BMI, and using an additive genetic model, logistic regression analysis revealed no association between rs290487 and type 2 diabetes (OR = 1.015, 95 % CI 0.949-1.087, p = 0.662). No association was found between rs290487 and type 2 diabetes in northern and southern Chinese population separately.

Conclusions: In summary, we have found no association between rs290487 and type 2 diabetes in Chinese population. This SNP is unlikely an influential genetic variant with type 2 diabetes in Chinese population.

语种英语
WOS记录号WOS:000325635000003
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60054
专题北京大学第二临床医学院
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Peking Univ Diabet Ctr, Beijing 100044, Peoples R China
2.China Japan Friendship Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Ren, Q.,Xiao, J.,Han, X.,et al. Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis[J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,2013,121(9):526-530.
APA Ren, Q.,Xiao, J.,Han, X.,Luo, Y.,Yang, W.,&Ji, L..(2013).Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis.EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,121(9),526-530.
MLA Ren, Q.,et al."Rs290487 of TCF7L2 Gene is not Associated with Type 2 Diabetes in Chinese Han Population: a Case Control Study and Meta-analysis".EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES 121.9(2013):526-530.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ren, Q.]的文章
[Xiao, J.]的文章
[Han, X.]的文章
百度学术
百度学术中相似的文章
[Ren, Q.]的文章
[Xiao, J.]的文章
[Han, X.]的文章
必应学术
必应学术中相似的文章
[Ren, Q.]的文章
[Xiao, J.]的文章
[Han, X.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。