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学科主题: 临床医学
题名:
Role of arachidonoylethanolamine in blood pressure regulation in volume-resistant patients on peritoneal dialysis
作者: Bai, Qiong1; Zhang, Jing1; Zhang, Ai-Hua1; Cheng, Li-Tao1; Duan, Jing-Li2; He, Lian1; Luo, Ya-Jun1; Fan, Min-Hua1; Wang, Yue1; Wang, Tao1
关键词: Arachidonoylethanolamine ; Continuous ambulatory peritoneal dialysis ; Volume overload ; Hypertension
刊名: INTERNATIONAL UROLOGY AND NEPHROLOGY
发表日期: 2012-12-01
DOI: 10.1007/s11255-012-0153-9
卷: 44, 期:6, 页:1855-1860
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: MEASURING DEVICES ; HYPERTENSION ; PROTOCOL
英文摘要:

In this study we explored the possible role of arachidonoylethanolamine (AEA) in regulating blood pressure in patients on continuous ambulatory peritoneal dialysis (CAPD). One hundred and five patients on CAPD were enrolled. Volume status was evaluated by the overhydration (OH) value obtained by bioimpedance analysis. OH < 2.0 kg was defined as normal volume (NV) and OH >= 2.0 kg as high volume (HV). Home mean systolic blood pressure <130 mmHg was defined as controlled hypertension (CHT) and >= 130 mmHg as uncontrolled hypertension (UHT). The patients were divided into four subgroups: (1) controlled hypertension with normal volume (CHT-NV), (2) controlled hypertension with high volume (CHT-HV), (3) uncontrolled hypertension with normal volume (UHT-NV), and (4) uncontrolled hypertension with high volume (UHT-HV). AEA was measured by ultra performance liquid chromatography-tandem mass spectrometry. AEA was significantly higher in the HV group as compared with the NV group (P < 0.05). In addition, AEA was also significantly higher in the CHT-HV group as compared with the UHT-NV group (P < 0.05). These results may suggest a compensatory function of AEA and TRPV1 pathway to lower blood pressure during volume expansion in CAPD patients.

语种: 英语
所属项目编号: 30800522 ; 200800011034 ; YZZ05-5-34
项目资助者: National Natural Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education ; Peking University Third Hospital Key Program Grant
WOS记录号: WOS:000313523000034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60064
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Peking Univ, Dept Nephrol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pharmacol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Bai, Qiong,Zhang, Jing,Zhang, Ai-Hua,et al. Role of arachidonoylethanolamine in blood pressure regulation in volume-resistant patients on peritoneal dialysis[J]. INTERNATIONAL UROLOGY AND NEPHROLOGY,2012,44(6):1855-1860.
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