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Role of arachidonoylethanolamine in blood pressure regulation in volume-resistant patients on peritoneal dialysis
Bai, Qiong1; Zhang, Jing1; Zhang, Ai-Hua1; Cheng, Li-Tao1; Duan, Jing-Li2; He, Lian1; Luo, Ya-Jun1; Fan, Min-Hua1; Wang, Yue1; Wang, Tao1
关键词Arachidonoylethanolamine Continuous ambulatory peritoneal dialysis Volume overload Hypertension
刊名INTERNATIONAL UROLOGY AND NEPHROLOGY
2012-12-01
DOI10.1007/s11255-012-0153-9
44期:6页:1855-1860
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]MEASURING DEVICES ; HYPERTENSION ; PROTOCOL
英文摘要

In this study we explored the possible role of arachidonoylethanolamine (AEA) in regulating blood pressure in patients on continuous ambulatory peritoneal dialysis (CAPD). One hundred and five patients on CAPD were enrolled. Volume status was evaluated by the overhydration (OH) value obtained by bioimpedance analysis. OH < 2.0 kg was defined as normal volume (NV) and OH >= 2.0 kg as high volume (HV). Home mean systolic blood pressure <130 mmHg was defined as controlled hypertension (CHT) and >= 130 mmHg as uncontrolled hypertension (UHT). The patients were divided into four subgroups: (1) controlled hypertension with normal volume (CHT-NV), (2) controlled hypertension with high volume (CHT-HV), (3) uncontrolled hypertension with normal volume (UHT-NV), and (4) uncontrolled hypertension with high volume (UHT-HV). AEA was measured by ultra performance liquid chromatography-tandem mass spectrometry. AEA was significantly higher in the HV group as compared with the NV group (P < 0.05). In addition, AEA was also significantly higher in the CHT-HV group as compared with the UHT-NV group (P < 0.05). These results may suggest a compensatory function of AEA and TRPV1 pathway to lower blood pressure during volume expansion in CAPD patients.

语种英语
WOS记录号WOS:000313523000034
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60064
专题北京大学第三临床医学院_肾内科
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Dept Nephrol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pharmacol, Hosp 3, Beijing 100191, Peoples R China
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GB/T 7714
Bai, Qiong,Zhang, Jing,Zhang, Ai-Hua,et al. Role of arachidonoylethanolamine in blood pressure regulation in volume-resistant patients on peritoneal dialysis[J]. INTERNATIONAL UROLOGY AND NEPHROLOGY,2012,44(6):1855-1860.
APA Bai, Qiong.,Zhang, Jing.,Zhang, Ai-Hua.,Cheng, Li-Tao.,Duan, Jing-Li.,...&Wang, Tao.(2012).Role of arachidonoylethanolamine in blood pressure regulation in volume-resistant patients on peritoneal dialysis.INTERNATIONAL UROLOGY AND NEPHROLOGY,44(6),1855-1860.
MLA Bai, Qiong,et al."Role of arachidonoylethanolamine in blood pressure regulation in volume-resistant patients on peritoneal dialysis".INTERNATIONAL UROLOGY AND NEPHROLOGY 44.6(2012):1855-1860.
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