IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice
Xu, Yajun; Tang, Yunan; Li, Yong
关键词alcohol folic acid brain proteome fetal alcohol syndrome
刊名BRITISH JOURNAL OF NUTRITION
2008-03-01
DOI10.1017/S0007114507812074
99期:3页:455-461
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]NEURAL-TUBE DEFECTS ; NERVOUS-SYSTEM ; NEURODEVELOPMENTAL DISORDER ; BINDING-PROTEIN ; MOUSE FETUSES ; EXPOSURE ; ETHANOL ; SUPPLEMENTATION ; PREGNANCY ; BEHAVIOR
英文摘要

Maternal alcohol consumption during pregnancy can induce central nervous system abnormalities in the fetus, and folic acid supplementation can reverse some of the effects. The objective of the present study was to investigate prenatal alcohol exposure-induced fetal brain proteome alteration and the protective effect of folic acid using proteomic techniques. Alcohol (5.0g/kg) was given intragastrically from gestational day (GD) 6 to 15, with or without 60.0 mg folic acid/kg given intragastrically during GD1-16 to pregnant Balb/c mice. The control group received distilled water only. Results of litter evaluation on GD18 showed that supplementation of folic acid reversed the prevalence of microcephaly induced by alcohol. Proteomic analysis indicated that, under the dosage of the present investigation, folic acid mainly reversed the alcohol-altered proteins involved in energy production, signal pathways and protein translation, which are all important for central nervous system development.

语种英语
WOS记录号WOS:000253583000002
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60065
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, Yajun,Tang, Yunan,Li, Yong. Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice[J]. BRITISH JOURNAL OF NUTRITION,2008,99(3):455-461.
APA Xu, Yajun,Tang, Yunan,&Li, Yong.(2008).Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice.BRITISH JOURNAL OF NUTRITION,99(3),455-461.
MLA Xu, Yajun,et al."Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice".BRITISH JOURNAL OF NUTRITION 99.3(2008):455-461.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Yajun]的文章
[Tang, Yunan]的文章
[Li, Yong]的文章
百度学术
百度学术中相似的文章
[Xu, Yajun]的文章
[Tang, Yunan]的文章
[Li, Yong]的文章
必应学术
必应学术中相似的文章
[Xu, Yajun]的文章
[Tang, Yunan]的文章
[Li, Yong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。