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学科主题: 公共卫生
题名:
Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice
作者: Xu, Yajun; Tang, Yunan; Li, Yong
关键词: alcohol ; folic acid ; brain proteome ; fetal alcohol syndrome
刊名: BRITISH JOURNAL OF NUTRITION
发表日期: 2008-03-01
DOI: 10.1017/S0007114507812074
卷: 99, 期:3, 页:455-461
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: NEURAL-TUBE DEFECTS ; NERVOUS-SYSTEM ; NEURODEVELOPMENTAL DISORDER ; BINDING-PROTEIN ; MOUSE FETUSES ; EXPOSURE ; ETHANOL ; SUPPLEMENTATION ; PREGNANCY ; BEHAVIOR
英文摘要:

Maternal alcohol consumption during pregnancy can induce central nervous system abnormalities in the fetus, and folic acid supplementation can reverse some of the effects. The objective of the present study was to investigate prenatal alcohol exposure-induced fetal brain proteome alteration and the protective effect of folic acid using proteomic techniques. Alcohol (5.0g/kg) was given intragastrically from gestational day (GD) 6 to 15, with or without 60.0 mg folic acid/kg given intragastrically during GD1-16 to pregnant Balb/c mice. The control group received distilled water only. Results of litter evaluation on GD18 showed that supplementation of folic acid reversed the prevalence of microcephaly induced by alcohol. Proteomic analysis indicated that, under the dosage of the present investigation, folic acid mainly reversed the alcohol-altered proteins involved in energy production, signal pathways and protein translation, which are all important for central nervous system development.

语种: 英语
WOS记录号: WOS:000253583000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60065
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Yajun,Tang, Yunan,Li, Yong. Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice[J]. BRITISH JOURNAL OF NUTRITION,2008,99(3):455-461.
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