IR@PKUHSC  > 北京大学第一临床医学院  > 消化科
学科主题临床医学
Loss of XIAP sensitizes colon cancer cells to PPAR gamma independent antitumor effects of troglitazone and 15-PGJ2
Qiao, Liang1; Dai, Yun1,2; Gu, Qing1,2; Chan, Kwok Wah3; Ma, Juan1; Lan, H. Y.1; Zou, Bing1; Rocken, Christoph4; Ebert, Matthias P. A.5; Wong, Benjamin C. Y.1
关键词colon cancer PPAR gamma XIAP ligands therapy
刊名CANCER LETTERS
2008-09-18
DOI10.1016/j.canlet.2008.04.003
268期:2页:260-271
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ACTIVATED-RECEPTOR-GAMMA ; HUMAN HEPATOCELLULAR-CARCINOMA ; X-LINKED INHIBITOR ; TUMOR-GROWTH ; COLORECTAL-CANCER ; IN-VIVO ; PERITONEAL METASTASIS ; INDUCED APOPTOSIS ; LINOLEIC-ACID ; KAPPA-B
英文摘要

We investigated whether the anticancer effect of a combination of XIAP down-regulation and PPAR gamma activation on colon cancer is PPAR gamma receptor dependent. HCT116-XIAP(+/+) cells and HCT116-XIAP(-/-) cells were treated with troglitazone or 15-deoxy-Delta(12,14)-prostaglandin J2 (15-PGJ2) with or without prior exposure to PPAR gamma inhibitor GW9662. Cell proliferation and apoptosis was evaluated. Athymic mice carrying HCT116-XIAP(-/-) cells-derived tumors were treated with troglitazone in the presence or absence of GW9662. Inhibition of cell proliferation and induction of apoptosis by troglitazone and 15-PGJ2 were more prominent in HCT116-XIAP(-/-) cells. PPAR gamma ligand-induced growth inhibition, apoptosis, caspase and PARP cleavage could not be blocked by GW9662. Troglitazone significantly retarded growth of xenograft tumors and this effect was not blocked by GW9662. Marked apoptosis and an up-regulation of E-cadherin were observed in xenograft tumor tissues, and GW9662 did not affect these effects. Thus, a combination of XIAP down-regulation and PPAR gamma ligands exert a significant anticancer effect in colon cancer via a PPAR gamma independent pathway. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000259898500009
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60066
Collection北京大学第一临床医学院_消化科
作者单位1.Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China
3.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
4.Charite Univ Med Berlin, Inst Pathol, D-13353 Berlin, Germany
5.Tech Univ Munich, Klinikum Rechts Isar, Dept Med 2, D-8000 Munich, Germany
Recommended Citation
GB/T 7714
Qiao, Liang,Dai, Yun,Gu, Qing,et al. Loss of XIAP sensitizes colon cancer cells to PPAR gamma independent antitumor effects of troglitazone and 15-PGJ2[J]. CANCER LETTERS,2008,268(2):260-271.
APA Qiao, Liang.,Dai, Yun.,Gu, Qing.,Chan, Kwok Wah.,Ma, Juan.,...&Wong, Benjamin C. Y..(2008).Loss of XIAP sensitizes colon cancer cells to PPAR gamma independent antitumor effects of troglitazone and 15-PGJ2.CANCER LETTERS,268(2),260-271.
MLA Qiao, Liang,et al."Loss of XIAP sensitizes colon cancer cells to PPAR gamma independent antitumor effects of troglitazone and 15-PGJ2".CANCER LETTERS 268.2(2008):260-271.
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