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Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin
Li, Lei1; Hu, Weimin1; Jia, Yanxing1,2
关键词Total synthesis Cyclic peptides Natural product Tandem reaction
刊名TETRAHEDRON
2014-10-21
DOI10.1016/j.tet.2014.05.082
70期:42页:7753-7762
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]ANTIMITOTIC BICYCLIC PEPTIDES ; CENTRAL TRYPTOPHAN RESIDUE ; EFFICIENT TOTAL-SYNTHESIS ; SUZUKI-MIYAURA REACTION ; CELOSIA-ARGENTEA ; ASYMMETRIC-SYNTHESIS ; LAPORTEA-MOROIDES ; ORGANIC-SYNTHESIS ; DIRECT ANNULATION ; FACILE SYNTHESIS
英文摘要

An account of the total synthesis of stephanotic acid methyl ester and celogentin C is presented. The present synthesis features a tandem asymmetric Michael addition/bromination sequence for the synthesis of leucine-tryptophan moiety, and an oxidative coupling reaction to form the tryptophan-imidazole linkage. Moreover, the total synthesis of moroidin had also been studied, and three different synthetic strategies for the construction of the right-hand ring of moroidin were studied. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000342711300023
项目编号21290180 ; 20972007 ; 2010CB833200
资助机构National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; State Key Laboratory of Drug Research
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/60070
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714
Li, Lei,Hu, Weimin,Jia, Yanxing. Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin[J]. TETRAHEDRON,2014,70(42):7753-7762.
APA Li, Lei,Hu, Weimin,&Jia, Yanxing.(2014).Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin.TETRAHEDRON,70(42),7753-7762.
MLA Li, Lei,et al."Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin".TETRAHEDRON 70.42(2014):7753-7762.
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