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学科主题: 药学
题名:
Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin
作者: Li, Lei1; Hu, Weimin1; Jia, Yanxing1,2
关键词: Total synthesis ; Cyclic peptides ; Natural product ; Tandem reaction
刊名: TETRAHEDRON
发表日期: 2014-10-21
DOI: 10.1016/j.tet.2014.05.082
卷: 70, 期:42, 页:7753-7762
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ANTIMITOTIC BICYCLIC PEPTIDES ; CENTRAL TRYPTOPHAN RESIDUE ; EFFICIENT TOTAL-SYNTHESIS ; SUZUKI-MIYAURA REACTION ; CELOSIA-ARGENTEA ; ASYMMETRIC-SYNTHESIS ; LAPORTEA-MOROIDES ; ORGANIC-SYNTHESIS ; DIRECT ANNULATION ; FACILE SYNTHESIS
英文摘要:

An account of the total synthesis of stephanotic acid methyl ester and celogentin C is presented. The present synthesis features a tandem asymmetric Michael addition/bromination sequence for the synthesis of leucine-tryptophan moiety, and an oxidative coupling reaction to form the tryptophan-imidazole linkage. Moreover, the total synthesis of moroidin had also been studied, and three different synthetic strategies for the construction of the right-hand ring of moroidin were studied. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 21290180 ; 20972007 ; 2010CB833200
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; State Key Laboratory of Drug Research
WOS记录号: WOS:000342711300023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60070
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

Recommended Citation:
Li, Lei,Hu, Weimin,Jia, Yanxing. Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin[J]. TETRAHEDRON,2014,70(42):7753-7762.
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