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学科主题: 基础医学
题名:
Metabolic syndrome and chronic kidney disease
作者: Ruan, Xiongzhong2,3; Guan, Youfei1
关键词: chronic renal disease ; insulin resistance ; metabolic syndrome
刊名: JOURNAL OF DIABETES
发表日期: 2009-12-01
DOI: 10.1111/j.1753-0407.2009.00042.x
卷: 1, 期:4, 页:236-245
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要:

The prevalence of metabolic syndrome (MetS) is increasing worldwide in both developing and developed countries. Experimental and clinical studies have revealed that MetS plays an important role in the development of chronic kidney disease (CKD), which leads to end-stage renal disease. Emerging evidence also suggests that CKD may actually cause MetS since the kidney is an important organ of glucose and lipid homeostasis. Although multiple mechanisms have been shown to be involved in the pathogenesis of MetS, insulin resistance appears to be a central pathophysiological factor contributing to MetS. In this review we will discuss the association of MetS with insulin resistance and CKD, and the renal pathophysiological changes associated with MetS.

语种: 英语
所属项目编号: 2006CB503907 ; 30530340/30725033
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation
WOS记录号: WOS:000208415200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/60074
Appears in Collections:基础医学院_北京大学糖尿病中心_期刊论文

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作者单位: 1.Beijing Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Ctr Diabet, Beijing 100191, Peoples R China
2.UCL, Sch Med, Ctr Nephrol, London W1N 8AA, England
3.Chongqing Med Univ, Ctr Lipid Res, Chongqing, Peoples R China

Recommended Citation:
Ruan, Xiongzhong,Guan, Youfei. Metabolic syndrome and chronic kidney disease[J]. JOURNAL OF DIABETES,2009,1(4):236-245.
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